This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects
Last updated: 4 years ago
Subscribe
News
- Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
- First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
- Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
- Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
- INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
- New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
- New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
- Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
- Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
- New radiation therapy shows promise for treating essential tremor Jun 14, 2019
Research
- Evaluation of retinal microvascular changes with OCT-A in Parkinson disease and essential tremor Dec 9, 2024
- Essential tremor – drug treatments present and future Dec 8, 2024
- Closed-loop systems for deep brain stimulation to treat neuropsychiatric disorders Dec 7, 2024
- Serum Neurofilament Light-Chain Levels in Essential Tremor: A Replication Study Dec 3, 2024
- Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor Nov 26, 2024
- Applied motor noise affects specific learning mechanisms during short-term adaptation to novel movement dynamics Nov 26, 2024
- Clinical neurophysiology for tremor: Common questions in clinical practice Nov 23, 2024
- Strong connectivity to the sensorimotor cortex predicts clinical effectiveness of thalamic deep brain stimulation in essential tremor Nov 22, 2024
- Awake versus asleep deep brain stimulation targeting the caudal zona incerta for essential tremor Nov 22, 2024
- Subtle bradykinesia features are easier to identify and more prevalent than questionable dystonia in essential tremor Nov 20, 2024
- Efficacy and safety of stereotactic radiosurgery with gamma knife machine in patients with essential tremor: a systematic review and single-arm meta-analysis Nov 19, 2024
- White matter correlates of gait and balance dysfunction in essential tremor patients Nov 19, 2024
- An Open-Label Pilot Study of Non-Invasive Cervical Vagus Nerve Stimulation in Essential Tremor Nov 17, 2024
- Unsupervised definition of two clinical subtypes of Essential tremor and the underlying brain topology Nov 17, 2024
- Damage to the Contralateral Thalamus after Magnetic Resonance Imaging-guided, Focused Ultrasound Surgery for Essential Tremor: A Case Report Nov 15, 2024
- Differentiating Essential and Dystonic Head Tremor: Exploring Arm Position Effects Nov 15, 2024
- Combined graph convolutional networks with a multi-connection pattern to identify tremor-dominant Parkinson’s disease and essential tremor with resting tremor Nov 14, 2024
- A multimodal fusion network based on a cross-attention mechanism for the classification of Parkinsonian tremor and essential tremor Nov 14, 2024
- “Quality over quantity:” smaller, targeted lesions optimize quality of life outcomes after MR-guided focused ultrasound thalamotomy for essential tremor Nov 13, 2024
- Missing appointments in Parkinson´s Disease: A longitudinal study on the pattern of attendance and its effects on motor and non-motor symptoms, quality of life and disability progression Nov 12, 2024
- Shaking Up Essential Tremor: Peripheral Devices and Mechanical Strategies to Reduce Tremor Nov 11, 2024
- Exploring stereotactic radiosurgery for tremor using the Varian cone planning system Nov 8, 2024
- Essential tremor plus affect disease prognosis: A longitudinal study Nov 8, 2024
- Cranial Tremors in Essential Tremor: Prevalence, Anatomic Distribution and Predictors of Occurrence Nov 7, 2024
- Delayed clinical response to focused ultrasound thalamotomy in essential tremor in a patient with suboptimal skull density ratio – A case report Nov 7, 2024
- Differentiating Postural and Kinetic Tremor Responses to Deep Brain Stimulation in Essential Tremor Nov 7, 2024
- Limited Potential of Repetitive Transcranial Magnetic Stimulation for Treatment of Essential Tremor: A Systematic Review Nov 5, 2024
- Cerebellar Structural and N-Acetylaspartate, Choline, and Creatine Metabolic Profiles in Parkinson’s Disease and Essential Tremor Oct 31, 2024
- Polysomnographic Findings into Sleep Disorders in Essential Tremor and Essential Tremor Plus: A Comparison with Healthy Controls Oct 28, 2024
- Tremor Following Guillain Barre Syndrome Oct 25, 2024
- Tremor Severity and Operative Parameters Predict Imbalance in Patients Undergoing Focused Ultrasound Thalamotomy Oct 25, 2024
- Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor in Fahr’s Disease: Case Report Oct 21, 2024
- Technical Feasibility of Delineating the Thalamic Gustatory Tract Using Tractography Oct 21, 2024
- Treatment for essential tremor: a systematic review and Bayesian Model-based Network Meta-analysis of RCTs Oct 18, 2024
- Primary central nervous system diffuse large B-cell lymphoma with MYC and BCL2 rearrangements associated with deep brain stimulation device Oct 18, 2024
- Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer’s disease and primary age-related tauopathy Oct 14, 2024
- Microinstability of Major Joints in Movement Disorders: The Hidden Challenge Oct 14, 2024
- Non-motor symptoms in patients with Spinocerebellar ataxia type 12 Oct 13, 2024
- Severe and unclassifiable tremor Oct 13, 2024
- The Direct Medical Cost of Essential Tremor Oct 11, 2024
- Navigating Deep Brain Stimulation Targets: A Three-Dimensional Video Guide for Movement Disorders Oct 9, 2024
- Impact of SARS-CoV-2 Infection on Essential Tremor: A Retrospective Clinical and Kinematic Analysis Oct 8, 2024
- Cognitive-motor interference in people with essential tremor Oct 8, 2024
- Patient-reported treatment satisfaction in essential tremor: levels of satisfaction and predictors of satisfaction Oct 8, 2024
- Quantitative Tractography-Based Evaluations in Essential Tremor Patients after MRgFUS Thalamotomy Oct 4, 2024
- Nabiximols (NBX) suppresses tremor in a rat Harmaline model of essential tremor Oct 3, 2024
- Brain color-coded diffusion imaging: Utility of ACPC reorientation of gradients in healthy subjects and patients Oct 1, 2024
- MRI-guided focused ultrasound for essential tremor Oct 1, 2024
- Magnetic resonance-guided focused ultrasound thalamotomy for tremor Oct 1, 2024
- Four-tract tractography: multiparametric direct targeting of the dentatorubrothalamic tract Oct 1, 2024
- Essential Palatal Tremor Following COVID-19 Vaccine: A Case Report Sep 29, 2024
- Prediction of rTMS Efficacy in Patients with Essential Tremor: Biomarkers from Individual Resting-state EEG Network Sep 27, 2024
- Six Myths and Misconceptions about Essential Tremor Sep 25, 2024
- Reasons for Hospitalizations and Emergency Department Visits Among Patients with Essential Tremor Sep 23, 2024
- A new perspective on essential tremor: the potential etiologic role of Toxoplasma gondii and Toxocara spp Sep 17, 2024
- Cognitive outcomes following unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: findings from two cohorts Sep 17, 2024
- Responsive Deep Brain Stimulation: A New Hope for Controlling Stimulation-Induced Dysarthria in Essential Tremor Sep 17, 2024
- Mechanisms of tremor-modulating effects of primidone and propranolol in essential tremor Sep 13, 2024
- Use of Botulinum Toxin in Upper-Limb Tremor: Systematic Review and Perspectives Sep 13, 2024
- Essential tremor as a prodromal feature of Parkinson’s disease Sep 13, 2024
- Purkinje Cell Dendritic Swellings: A Postmortem Study of Essential Tremor and Other Cerebellar Degenerative Disorders Sep 3, 2024
- Secondary parkinsonism associated with focal brain lesions Sep 3, 2024
- Tremor Suppression Using Functional Electrical Stimulation Sep 2, 2024
- 3-T MR-guided focused ultrasound thalamotomy for tremor in patients with a cardiac pacemaker: case series and review of the literature Sep 1, 2024
- Minimum and early high-energy sonication protocol of MR-guided focused ultrasound thalamotomy for low-skull density ratio patients with essential tremor and Parkinson’s disease Sep 1, 2024
- Magnetic resonance-guided focused ultrasound in the treatment of refractory essential tremor: a systematic review and meta-analysis Sep 1, 2024
- Brain targeting for focused ultrasound essential tremor ablation: proceedings from the 2023 Focused Ultrasound Foundation workshop Sep 1, 2024
- Postmortem Fatty Acid Abnormalities in the Cerebellum of Patients with Essential Tremor Aug 31, 2024
- Exploring White Matter Microstructure with Symptom Severity and Outcomes Following Deep Brain Stimulation in Tremor Syndromes Aug 28, 2024
- Radiomics based on diffusion tensor imaging and 3D T1-weighted MRI for essential tremor diagnosis Aug 27, 2024
- Initial outcomes and safety of MR guided focused ultrasound (MRgFUS) thalamotomy for essential tremor of the first FUS Medical Unit in Portugal Aug 26, 2024
- Ethics of deep brain stimulation for neuropsychiatric disorders Aug 25, 2024
- Modulation of CB1 cannabinoid receptor alters the electrophysiological properties of cerebellar Purkinje cells in harmaline-induced essential tremor Aug 23, 2024
- Automated Sleep Detection in Movement Disorders Using Deep Brain Stimulation and Machine Learning Aug 23, 2024
- Effects of Low-Frequency Deep Brain Stimulation in Bilateral Zona Incerta for a Patient With Tremor and Cerebellar Ataxia Aug 21, 2024
- Predicting tremor improvement after MRgFUS thalamotomy in essential tremor from preoperative spontaneous brain activity: A machine learning approach Aug 16, 2024
- Frequency Coding in Essential Tremor-The Olivocerebellar Orchestra Conducts Its Own Symphony Aug 16, 2024
- AB058. Giant bilateral intraventricle ependymoma in pediatric patient with essential tremor as a main symptom: a rare case report Aug 15, 2024
- Multimodal neuroimaging to characterize symptom-specific networks in movement disorders Aug 14, 2024
- Thalamic ventral-Oralis complex/rostral zona incerta deep brain stimulation for midline tremor Aug 9, 2024
- Probabilistic Refinement of Focused Ultrasound Thalamotomy Targeting for Parkinson’s Disease Tremor Aug 9, 2024
- Frequency-Selective Suppression of Essential Tremor via Transcutaneous Spinal Cord Stimulation Aug 7, 2024
- The role of MRgFUS in the treatment of neuropsychiatric disorders: a state of the art Aug 5, 2024
- Phenomenological patterns and aetiological spectrum in patients visiting a tertiary care Movement disorders service in India: An observational study Aug 3, 2024
- Action tremor features discovery for essential tremor and Parkinson’s disease with explainable multilayer BiLSTM Aug 2, 2024
- Phantom-Enhanced High Mechanical Accuracy for Frame-Based Deep Brain Stimulation Aug 2, 2024
- Antibiotic-impregnated envelopes reduce the rate of surgical site infection in deep brain stimulation pulse generators: a comparative study Aug 1, 2024
- Development of a Tremor Detection Algorithm for Use in an Academic Movement Disorders Center Jul 31, 2024
- Focused neurological assessment to differentiate essential tremor from functional tremor Jul 29, 2024
- Safety and Efficacy of Staged, Bilateral Focused Ultrasound Thalamotomy in Essential Tremor: An Open-Label Clinical Trial Jul 29, 2024
- Bilateral Focused Ultrasound Thalamotomy for Tremor-Is It Really Safe? Jul 29, 2024
- The Use of Focused Ultrasound Ablation for Movement Disorders Jul 29, 2024
- Subjective and Objective Day-to-Day Performance Measures of People with Essential Tremor Jul 26, 2024
- Featuring the Features of the Featureless Tremor: A Statement about Essential Tremor Jul 26, 2024
- Tips and tricks in tremor treatment Jul 23, 2024
- Research hotspots and frontiers of essential tremor from 2013 to 2023: a visualization analysis based on CiteSpace Jul 22, 2024
- Functional Neurological Disorders Among Patients With Tremor Jul 21, 2024
- Deep brain stimulation for essential tremor in patients with ventriculomegaly Jul 18, 2024
- Distinguishing essential tremor from Parkinson’s disease: clinical and experimental tools Jul 17, 2024
- Double lesion MRgFUS thalamotomy for essential tremor: 4.5-year outcomes and framework for assessing loss of efficacy and tremor progression Jul 17, 2024
Clinical Trials
- The Use of the CUE1/CUE1+ in People With Parkinson’s Disease and Related Disorders Nov 21, 2024
- Deep Brain Frameless Radiosurgery for Drug Resistant Invalidating Tremor. Dose Escalation Pilot Study Nov 8, 2024
- A Study to Evaluate the Safety and Efficacy of Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor Nov 6, 2024
- Ultrasound Neuromodulation in Essential Tremor Sep 24, 2024
- 24-months Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson’s Disease and Essential Tremor Aug 26, 2024
- Motor Network Physiology Aug 7, 2024
- Impact of Sensory Electrical Stimulation on Sensation and Tremor May 24, 2024
- The Effect of Alcohol on Common Tremor Syndromes May 7, 2024
- Nonlinear Absorber in Essential Tremor Treatment May 2, 2024
- The Development of a System for the Measurement of Tremor Apr 26, 2024
- Upper Limb Tremor Reduction in Essential Tremor Patients Apr 2, 2024
- 3-D Tractography FUS Ablation for Essential Tremor Mar 26, 2024
- Directional Bilateral Thalamic Patterned Stimulation (Chronos) Mar 22, 2024
- Tolerability and Efficacy of Continuous Theta-burst Stimulation for Essential Tremor: A Randomized Study. Mar 15, 2024
- Acamprosate and Methazolamide for Essential Tremor Mar 15, 2024
- Assessment of the Safety and Efficacy of the Felix NeuroAI Wristband in Essential Tremor Jan 31, 2024
- Repetitive Transcranial Magnetic Stimulation Therapy in Essential Tremor Nov 27, 2023
- Essential 3 – Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET) Oct 17, 2023
- Prospective Study for Symptomatic Relief of ET With Cala Therapy Oct 12, 2023
- Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson’s Disease and Essential Tremor Sep 13, 2023
- A Study of Wearable Device in Essential Tremor Patients Aug 4, 2023
- Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET Aug 1, 2023
- Investigating LFP Correlates of TUS in Patients With Movement Disorders Jul 31, 2023
- GyroGlove Use in Essential Tremor Patients Jul 24, 2023
- The Development of a System for Measurement of Tremor Jul 21, 2023
- Cala ONE Device for Essential Tremor Jul 18, 2023
- Coordinated Reset Deep Brain Stimulation for Essential Tremor Jun 9, 2023
- Pilot Study of the Felix System in Patients With Essential Tremor and Parkinson’s Tremor May 6, 2023
- Evaluation of Bilateral Gamma Knife Thalamotomy in Patients Presenting With Severe Essential Tremor Apr 14, 2023
- Atlas Predicted DBS Settings in Essential Tremor Mar 27, 2023
- Transcranial Ultrasound Therapy of Essential Tremor Feb 23, 2023
- Electroclinical Correlates in Essential Tremor Jan 5, 2023
- Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor Dec 12, 2022
- MRgFUS Thalamotomy for Therapy-Resistant Tremor-related Disease With Low SDR Value Nov 22, 2022
- Gamma Knife Radiosurgery for Treatment of Essential Tremor Nov 22, 2022
- RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor Sep 14, 2022
- Algorithms for Programming DBS Systems for ET Aug 4, 2022
- Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands Jul 29, 2022
- Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor Jul 26, 2022
- Evaluate SAGE-547 in Participants With Essential Tremor Jun 29, 2022
- tSMS in Essential Tremor Jun 6, 2022
- The Swedish Essential Tremor (SWEET) Trial May 25, 2022
- A Clinical Trial of PRAX-114 in Participants With Essential Tremor May 24, 2022
- A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor May 9, 2022
- Neurophysiologic Assessment of ET Patients Treated by Vim DBS May 5, 2022
- Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia Apr 7, 2022
- Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation Apr 4, 2022
- Efficacy, Safety, and Pharmacokinetics of ES-481 in Adult Patients With Essential Tremors Feb 10, 2022
- Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor Jan 31, 2022
- Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma Jan 28, 2022
- Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation Jan 28, 2022
- Interphase Gap in Biphasic Stimulation in DBS for ET Jan 5, 2022
- Study to Evaluate SAGE-324 in Participants With Essential Tremors Dec 29, 2021
- Repetitive Transcranial Magnetic Stimulation in Essential Tremors Patients Dec 15, 2021
- A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET) Nov 17, 2021
- The Effects of Vibrotactile Stimulation in Patients With Movement Disorders Nov 4, 2021
- Neurofeedback Using Implanted Deep Brain Stimulation Electrodes Nov 1, 2021
- DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET) Oct 27, 2021
- Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001) Oct 22, 2021
- A Phase 2 RCT Study of CX-8998 for Essential Tremor Oct 22, 2021
- New Stereotactic Frame System for Neurosurgery Oct 14, 2021
- ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 16, 2021
- Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 8, 2021
- Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor Sep 8, 2021
- ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders Sep 8, 2021
- A Study to Evaluate the Effectiveness and Safety of ExAblate MRgFUS on Essential Tremor Sep 5, 2021
- [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson’s Diseases and Essential Tremor Sep 5, 2021
- Cyclic Deep Brain Stimulation in Essential Tremor Sep 2, 2021
- Cerebello-thalamo-cortical Coupling in Essential Tremor Aug 30, 2021
- A Clinical Trial of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- A Clinical Trial of 3 Doses of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives Aug 13, 2021
- Responsive Deep Brain Stimulator for Essential Tremor Aug 12, 2021
- Cortical-Basal Ganglia Speech Networks Aug 9, 2021
- Deep braIn Stimulation for Tremor TractographIC Versus Traditional Jul 28, 2021
- Sensory-specific Peripheral Stimulation for Tremor Management Jul 21, 2021
- Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity Jul 16, 2021
- Effects of Stimulation Patterns of Deep Brain Stimulation Jul 2, 2021
- Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson’s Disease and Tremor May 18, 2021
- Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor May 11, 2021
- UPDATED: Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Directional Versus Nondirectional DBS for ET Apr 2, 2021
- Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
- Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
- Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
- RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
- Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
- A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
- Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
- Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
- A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
- Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
- A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
- Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
- Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
- Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
- A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021
- Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
- Alternating Current Stimulation for Essential Tremor Sep 2, 2020
- Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
- Trial of Cannabis for Essential Tremor May 29, 2020