This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects
Last updated: 3 years ago
Subscribe
News
- Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
- First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
- Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
- Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
- INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
- New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
- New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
- Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
- Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
- New radiation therapy shows promise for treating essential tremor Jun 14, 2019
Research
- Sleep Disorders in Patients with Choreic Syndromes Jun 3, 2023
- Task Specific Tremor in Parkinson’s Disease Responds to Apomorphine Jun 2, 2023
- Assessment of Patients Receiving Short-Interval Botulinum Toxin Chemodenervation Treatment for Laryngeal Dystonia and Essential Tremor of the Vocal Tract May 25, 2023
- Diagnosis Versus Classification of Essential Tremor: A Research Perspective May 23, 2023
- Grey matter correlates of dystonic soft signs in essential tremor May 23, 2023
- Whole-brain network transitions within the framework of ignition and transfer entropy following VIM-MRgFUS in essential tremor patients May 23, 2023
- Cortical mean diffusivity is reliable in measuring brain abnormalities in drug-naïve essential tremor patients May 21, 2023
- Cognitive Performance as a Function of MAPT Haplotype: A Prospective Longitudinal Study of an Essential Tremor Cohort May 19, 2023
- Risk of neurodegenerative diseases in patients with sleep disorders: A nationwide population-based case-control study May 18, 2023
- Vestibular reflexes in essential tremor: abnormalities of ocular and cervical vestibular-evoked myogenic potentials are associated with the cerebellum and brainstem involvement May 18, 2023
- Alcohol and Ganaxolone Suppress Tremor via Extra-Synaptic GABAA Receptors in the Harmaline Model of Essential Tremor May 18, 2023
- Association of gout with brain reserve and vulnerability to neurodegenerative disease May 18, 2023
- Associations between cognitive function and a range of significant life events in an elderly essential tremor cohort study May 11, 2023
- Chemical suppression of harmaline-induced body tremor yields recovery of pairwise neuronal coherence in cerebellar nuclei neurons May 11, 2023
- Conversion Rate of Essential Tremor to Essential Tremor Parkinson Disease: Data From a Prospective Longitudinal Study May 10, 2023
- Acute stimulation with symmetric biphasic pulses induces less ataxia compared to cathodic pulses in DBS for essential tremor May 8, 2023
- Magnetic Resonance-Guided focused ultrasound surgery for Parkinson’s disease: A mini-review and comparison between deep brain stimulation May 5, 2023
- Cortical involvement in essential tremor with and without rest tremor: a machine learning study May 5, 2023
- How Sample Size Impacts Probabilistic Stimulation Maps in Deep Brain Stimulation May 3, 2023
- Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density May 2, 2023
- Modeling Instantaneous Firing Rate of Deep Brain Stimulation Target Neuronal Ensembles in the Basal Ganglia and Thalamus May 2, 2023
- Effect of Ventral Intermediate Nucleus Deep Brain Stimulation on Vocal Tremor in Essential Tremor May 2, 2023
- Locus coeruleus and substantia nigra neuromelanin magnetic resonance imaging differentiates Parkinson’s disease and essential tremor Apr 27, 2023
- Landscape and future directions of machine learning applications in closed-loop brain stimulation Apr 27, 2023
- Beta band oscillations in the motor thalamus are modulated by visuomotor coordination in essential tremor patients Apr 25, 2023
- Odds of Medical Comorbidities in Essential Tremor: Retrospective Analysis of a Large Claims Database in the United States Apr 25, 2023
- Cerebellar Transcranial Alternating Current Stimulation in Essential Tremor Patients with Thalamic Stimulation: A Proof-of-Concept Study Apr 25, 2023
- Tremor supression following treatment with MRgFUS: skull density ratio consistency and degree of posterior dentatorubrothalamic tract lesioning predicts long-term clinical outcomes in essential tremor Apr 24, 2023
- Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model Apr 23, 2023
- A Modified Technique for Interventional MRI-Guided Deep Brain Stimulation Using the ClearPoint System Apr 11, 2023
- Clinical Heterogeneity of Essential Tremor: Understanding Neural Substrates of Action Tremor Subtypes Apr 6, 2023
- The effect of standing posture on amplitude and variability of postural tremor in Parkinson’s disease Apr 3, 2023
- A Systematic Review Comparing Focused Ultrasound Surgery With Radiosurgery for Essential Tremor Apr 3, 2023
- 10 Years Follow-Up of Deep Brain Stimulation in the Caudal Zona Incerta/Posterior Subthalamic Area for Essential Tremor Mar 31, 2023
- The cognitive profile of essential tremor on the Repeatable Battery for the Assessment of Neuropsychological Status Mar 28, 2023
- Technical Issues of Vim-PSA Double-Target DBS for Essential Tremor Mar 28, 2023
- Top-down control of human motor thalamic neuronal activity during the auditory oddball task Mar 27, 2023
- Cavitation with low-energy sonication during focused ultrasound thalamotomy for a patient with tremor-dominant Parkinson’s disease: a potential risk Mar 26, 2023
- Limb Preference Changes after Focused-Ultrasound Thalamotomy for Tremor Mar 22, 2023
- Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China Mar 22, 2023
- The relationship of tremor severity with proximal and distal muscle strength and upper extremity functional skills in older adults with essential tremor Mar 17, 2023
- Postmortem Cerebellar Volume Is Not Reduced in Essential Tremor: A Comparison with Multiple System Atrophy and Controls Mar 14, 2023
- Current applications for magnetic resonance-guided focused ultrasound in the treatment of Parkinson’s disease Mar 13, 2023
- Diagnostic Uncertainties in Tremor Mar 13, 2023
- Quantification of Movement Error from Spiral Drawing Test Mar 13, 2023
- Gamma Knife Thalamotomy for Essential Tremor: A Retrospective Analysis Mar 11, 2023
- Depression Scores following Ventral Intermediate Nucleus Deep Brain Stimulation for Essential Tremor: A Meta-Analysis Mar 10, 2023
- Eye movement study in essential tremor patients and its clinical correlates Mar 9, 2023
- Global Epidemiology of Movement Disorders: Rare or Underdiagnosed? Mar 9, 2023
- History of Ablation Therapies in Neurosurgery Mar 9, 2023
- Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application Mar 7, 2023
- Globus pallidus internus deep brain stimulation evokes resonant neural activity in Parkinson’s disease Mar 6, 2023
- Feasibility of Magnetic Resonance-Compatible Accelerometers to Monitor Tremor Fluctuations During Magnetic Resonance-Guided Focused Ultrasound Thalamotomy: Technical Note Feb 24, 2023
- Application of optimized convolutional neural networks for early aided diagnosis of essential tremor: Automatic handwriting recognition and feature analysis Feb 22, 2023
- Tremor assessment scales before, during and after MRgFUS for essential tremor – results, recommendations and implications Feb 19, 2023
- Cerebellar repetitive transcranial magnetic stimulation versus propranolol for essential tremor Feb 18, 2023
- Prevalence and risk factors for abnormal tandem gait in patients with essential tremor syndrome: A cross-sectional study in Southwest China Feb 16, 2023
- The Influence of Fatigue on the Characteristics of Physiological Tremor and Hoffmann Reflex in Young Men Feb 15, 2023
- Essential tremor and the scales: Quality of life in essential tremor, the Fahn-Tolosa-Marin Tremor Rating Scale; and, the Bain and Findley Clinical Tremor Rating Scale Feb 14, 2023
- GABAA Receptor Subtype Specificity in Essential Tremor Feb 10, 2023
- TAOK1-related neurodevelopmental disorder: A new differential diagnosis for childhood-onset tremor? Feb 10, 2023
- MRgFUS thalamotomy for the treatment of tremor: evaluation of learning curve and operator’s experience impact on the procedural and clinical outcome Feb 10, 2023
- Arteriovenous fistula in functional motor disability Feb 7, 2023
- Risk factors of social anxiety in patients with essential tremor Feb 5, 2023
- Lateral cerebellothalamic tract activation underlies DBS therapy for Essential Tremor Feb 4, 2023
- T-type calcium channels as therapeutic targets in essential tremor and Parkinson’s disease Feb 4, 2023
- Additional Role of Midbrain F-18 FP-CIT Uptake on PET in Evaluation of Essential Tremor and Parkinsonism Feb 3, 2023
- Wearable sensor-based gait analysis to discriminate early Parkinson’s disease from essential tremor Feb 1, 2023
- Bilateral Radiofrequency Ventral Intermediate Thalamotomy for Essential Tremor Jan 31, 2023
- Investigation of Phase Shifts Using AUC Diagrams: Application to Differential Diagnosis of Parkinson’s Disease and Essential Tremor Jan 30, 2023
- Phenomenology and Physiology of Tacrolimus Induced Tremor Jan 30, 2023
- Floating door sign does not differentiate Parkinson’s disease from essential tremor Jan 27, 2023
- Glioblastoma, IDH-Wildtype, CNS WHO Grade 4, Associated with Deep Brain Stimulation in a Patient with Essential Tremor: Report of a Case with Molecular Characterization, and Review of the Literature Jan 27, 2023
- Reply to: Glioblastoma, IDH-Wildtype, CNS WHO Grade 4, Associated with Deep Brain Stimulation in a Patient with Essential Tremor: Report of a Case with Molecular Characterization and Review of the Literature Jan 27, 2023
- Connectomic Basis for Tremor Control in Stereotactic Radiosurgical Thalamotomy Jan 26, 2023
- Gait Function after High-Intensity Focused Ultrasound Thalamotomy for Essential Tremor: Searching for Technique Optimization Jan 25, 2023
- Focused Ultrasound Thalamotomy: Correlation of Postoperative Imaging with Neuropathological Findings Jan 25, 2023
- Cerebellar α6GABAA Receptors as a Therapeutic Target for Essential Tremor: Proof-of-Concept Study with Ethanol and Pyrazoloquinolinones Jan 25, 2023
- Perampanel: Medical Alternative for Essential Tremor? Jan 25, 2023
- Essential Tremor accentuates the pattern of tremor-band coherence between upper-limb muscles Jan 25, 2023
- Chronic inflammatory demyelinating polyradiculoneuropathy associated tremor: Phenotype and pathogenesis Jan 24, 2023
- Han family with essential tremor caused by the P421L variant of the TENM4 gene in China Jan 22, 2023
- Commentary: Time trends in the incidence of essential tremor: Evidences from UK and France primary care data Jan 19, 2023
- GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats Jan 19, 2023
- An Institutional Experience of Directional Deep Brain Stimulation and a Review of the Literature Jan 17, 2023
- Limb positioning and magnitude of postural tremor ratings: A study of 100 essential tremor cases Jan 12, 2023
- Expression of Concern: Hcn1 Is a Tremorgenic Genetic Component in a Rat Model of Essential Tremor Jan 11, 2023
- Reproducibility of cerebellar involvement as quantified by consensus structural MRI biomarkers in advanced essential tremor Jan 11, 2023
- Brain microstructural changes in essential tremor patients and correlations with clinical characteristics: a diffusion kurtosis imaging study Jan 6, 2023
- Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains Jan 5, 2023
- Classification of Kinematic and Electromyographic Signals Associated with Pathological Tremor Using Machine and Deep Learning Jan 5, 2023
- Differential contributions of depression, apathy, and anxiety to neuropsychological performance in Parkinson’s disease versus essential tremor Jan 4, 2023
- Upper Limb Function but Not Proprioception is Impaired in Essential Tremor: A Between-Groups Study and Causal Mediation Analysis Jan 3, 2023
- Infantile Tremor Syndrome With Movement Disorder: Current Perspective Dec 29, 2022
- Diagnosis and Treatment of Tremor in Parkinson’s Disease Using Mechanical Devices Dec 28, 2022
- Tremor Dec 27, 2022
- The effect of tremor on disability assessment in chronic inflammatory demyelinating polyradiculoneuropathy Dec 26, 2022
- Noninvasive neuroimaging provides evidence for deterioration of the glymphatic system in Parkinson’s disease relative to essential tremor Dec 24, 2022
- Skin-related complications following deep brain stimulation surgery: A single-center retrospective analysis of 525 patients who underwent DBS surgery Dec 23, 2022
- Analyses of correct responses and errors on measures of verbal fluency among Parkinson’s disease and essential tremor patients Dec 22, 2022
Clinical Trials
- Pilot Study of the Felix System in Patients With Essential Tremor and Parkinson’s Tremor May 6, 2023
- Evaluation of Bilateral Gamma Knife Thalamotomy in Patients Presenting With Severe Essential Tremor Apr 14, 2023
- Atlas Predicted DBS Settings in Essential Tremor Mar 27, 2023
- Transcranial Ultrasound Therapy of Essential Tremor Feb 23, 2023
- Electroclinical Correlates in Essential Tremor Jan 5, 2023
- Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor Dec 12, 2022
- MRgFUS Thalamotomy for Therapy-Resistant Tremor-related Disease With Low SDR Value Nov 22, 2022
- Gamma Knife Radiosurgery for Treatment of Essential Tremor Nov 22, 2022
- RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor Sep 14, 2022
- Algorithms for Programming DBS Systems for ET Aug 4, 2022
- Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands Jul 29, 2022
- Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor Jul 26, 2022
- Evaluate SAGE-547 in Participants With Essential Tremor Jun 29, 2022
- tSMS in Essential Tremor Jun 6, 2022
- The Swedish Essential Tremor (SWEET) Trial May 25, 2022
- A Clinical Trial of PRAX-114 in Participants With Essential Tremor May 24, 2022
- A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor May 9, 2022
- Neurophysiologic Assessment of ET Patients Treated by Vim DBS May 5, 2022
- Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia Apr 7, 2022
- Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation Apr 4, 2022
- Efficacy, Safety, and Pharmacokinetics of ES-481 in Adult Patients With Essential Tremors Feb 10, 2022
- Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor Jan 31, 2022
- Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma Jan 28, 2022
- Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation Jan 28, 2022
- Interphase Gap in Biphasic Stimulation in DBS for ET Jan 5, 2022
- Study to Evaluate SAGE-324 in Participants With Essential Tremors Dec 29, 2021
- Repetitive Transcranial Magnetic Stimulation in Essential Tremors Patients Dec 15, 2021
- A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET) Nov 17, 2021
- The Effects of Vibrotactile Stimulation in Patients With Movement Disorders Nov 4, 2021
- Neurofeedback Using Implanted Deep Brain Stimulation Electrodes Nov 1, 2021
- DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET) Oct 27, 2021
- Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001) Oct 22, 2021
- A Phase 2 RCT Study of CX-8998 for Essential Tremor Oct 22, 2021
- New Stereotactic Frame System for Neurosurgery Oct 14, 2021
- ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 16, 2021
- Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 8, 2021
- Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor Sep 8, 2021
- ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders Sep 8, 2021
- A Study to Evaluate the Effectiveness and Safety of ExAblate MRgFUS on Essential Tremor Sep 5, 2021
- [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson’s Diseases and Essential Tremor Sep 5, 2021
- Cyclic Deep Brain Stimulation in Essential Tremor Sep 2, 2021
- Cerebello-thalamo-cortical Coupling in Essential Tremor Aug 30, 2021
- A Clinical Trial of 3 Doses of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- A Clinical Trial of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives Aug 13, 2021
- Responsive Deep Brain Stimulator for Essential Tremor Aug 12, 2021
- Cortical-Basal Ganglia Speech Networks Aug 9, 2021
- Deep braIn Stimulation for Tremor TractographIC Versus Traditional Jul 28, 2021
- Sensory-specific Peripheral Stimulation for Tremor Management Jul 21, 2021
- Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity Jul 16, 2021
- Effects of Stimulation Patterns of Deep Brain Stimulation Jul 2, 2021
- Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson’s Disease and Tremor May 18, 2021
- Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor May 11, 2021
- UPDATED: Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Directional Versus Nondirectional DBS for ET Apr 2, 2021
- Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
- Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
- Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
- RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
- Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
- A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
- Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
- Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
- A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
- Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
- A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
- Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
- Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
- Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
- A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021
- Wearable Sensor for Responsive DBS for ET Jan 14, 2021
- Optimization of VIM Targeting in Essential Tremor Surgery Jan 12, 2021
- A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Dec 23, 2020
- Trial of Cannabis for Essential Tremor Dec 21, 2020
- Mapping the Target for the MRgFUS Treatment of Tremor Dec 10, 2020
- Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings Dec 8, 2020
- Deep Brain Stimulation Therapy in Movement Disorders Nov 17, 2020
- Physiology, Imaging and Modeling of Essential Tremor Nov 12, 2020
- Demand-driven Management of Essential Tremor Nov 5, 2020
- Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? Oct 30, 2020
- Masotherapy With Neural Tension in Patients With Parkinson’s Disease Oct 23, 2020
- A Clinical Study to Evaluate CAD-1883 in Essential Tremor Oct 14, 2020
- Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
- Alternating Current Stimulation for Essential Tremor Sep 2, 2020
- Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
- Trial of Cannabis for Essential Tremor May 29, 2020
