This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects
Last updated: 1 year ago
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News
- Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
- First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
- Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
- Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
- INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
- New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
- New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
- Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
- Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
- New radiation therapy shows promise for treating essential tremor Jun 14, 2019
Research
- Nucleus accumbens as a stereotactic target for the treatment of addictions in humans: a literature review Oct 11, 2021
- Tremor and Rigidity in Patients with Parkinson’s Disease: Emphasis on Epidemiology, Pathophysiology and Contributing Factors Oct 8, 2021
- Clinical and laboratory features of children with tremor: a single-center experience Oct 7, 2021
- Connectivity correlates to predict essential tremor deep brain stimulation outcome: Evidence for a common treatment pathway Oct 4, 2021
- Editorial: Tremor Syndromes: Current Concepts and Future Perspectives Sep 27, 2021
- Evaluating and Optimizing Dentato-Rubro-Thalamic-Tract Deterministic Tractography in Deep Brain Stimulation for Essential Tremor Sep 25, 2021
- Direct targeting of the ventral intermediate nucleus of the thalamus in deep brain stimulation for essential tremor: a prospective study with comparison to a historical cohort Sep 24, 2021
- Long-Lasting Desynchronization Effects of Coordinated Reset Stimulation Improved by Random Jitters Sep 24, 2021
- Utility of tremor electrophysiology studies Sep 24, 2021
- The role of tractography in the localisation of the Vim nucleus of the thalamus and the dentatorubrothalamic tract for the treatment of tremor Sep 22, 2021
- Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson’s disease and essential tremor. A case control biomarker study Sep 21, 2021
- Lesions of the cerebello-thalamic tract rather than the ventral intermediate nucleus determine the outcome of focused ultrasound therapy in essential tremor: A 3T and 7T MRI-study Sep 20, 2021
- Wearable sensor-driven responsive deep brain stimulation for essential tremor Sep 20, 2021
- Mirror Movements in Acquired Neurological Disorders: A Mini-Review Sep 19, 2021
- Patient-specific effects on sonication heating efficiency during magnetic resonance-guided focused ultrasound thalamotomy Sep 16, 2021
- Reducing Ataxic Side Effects from Ventral Intermediate Nucleus of the Thalamus Deep Brain Stimulation Implantation in Essential Tremor: Potential Advantages of Directional Stimulation Sep 15, 2021
- Thalamic Deep Brain Stimulation May Improve Restless Legs Syndrome in Patients With Essential Tremor Sep 14, 2021
- Gastrointestinal disorders in hyperkinetic movement disorders and ataxia Sep 13, 2021
- Considerations Using Harmaline for a Primate Model of Tremor Sep 13, 2021
- Comprehensive Evaluation of Factors Affecting Tremor Relapse after MRgFUS Thalamotomy: A Case-Control Study Sep 8, 2021
- Bilateral Magnetic Resonance Imaging-Guided Focused Ultrasound Thalamotomy for Essential Tremor Sep 7, 2021
- Essential tremor amplitude modulation by median nerve stimulation Sep 6, 2021
- Drawing Direction Effect on a Task’s Performance Characteristics among People with Essential Tremor Aug 31, 2021
- Features of “ET plus” correlate with age and tremor duration: “ET plus” may be a disease stage rather than a subtype of essential tremor Aug 31, 2021
- Techniques, Indications, and Outcomes in Magnetic Resonance-guided Focused Ultrasound Thalamotomy for Tremor Aug 31, 2021
- Transcranial Magnetic Stimulation in Tremor Syndromes: Pathophysiologic Insights and Therapeutic Role Aug 26, 2021
- Noninvasive Thalamotomy for Refractory Tremor by Frameless Radiosurgery Aug 25, 2021
- Use of non-invasive stimulation in movement disorders: a critical review Aug 25, 2021
- Adaptive deep brain stimulation (aDBS) Aug 23, 2021
- New developments for spinal cord stimulation Aug 23, 2021
- The sensitivity of ECG contamination to surgical implantation site in brain computer interfaces Aug 21, 2021
- Evaluation of movement and brain activity Aug 19, 2021
- Phonatory Characteristics of Male Patients with Classic Essential Tremor Aug 16, 2021
- Plasma amino acids in patients with essential tremor Aug 16, 2021
- Double lesion MRgFUS treatment of essential tremor targeting the thalamus and posterior sub-thalamic area: preliminary study with two year follow-up Aug 12, 2021
- Posterior Subthalamic Area, Pallidothalamic Tract, and Pedunculopontine Nucleus:Deep Brain Stimulation Targets for Parkinson’s Disease and Essential Tremor Aug 10, 2021
- Radiofrequency Lesioning Surgery for Movement Disorders Aug 10, 2021
- Surgical Technique of Ventral Intermediate Thalamic Deep Brain Stimulation Aug 10, 2021
- Stereotactic Surgery for Tremor Aug 10, 2021
- Mood and emotional disorders associated with parkinsonism, Huntington disease, and other movement disorders Aug 10, 2021
- A Review on Wearable Technologies for Tremor Suppression Aug 8, 2021
- Clinical perspectives of adaptive deep brain stimulation Aug 7, 2021
- Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies Aug 7, 2021
- Optimal closed-loop deep brain stimulation using multiple independently controlled contacts Aug 6, 2021
- Asleep deep brain stimulation with intraoperative magnetic resonance guidance: a single-institution experience Aug 5, 2021
- Deep Brain Stimulation for Tremor: Update on Long-Term Outcomes, Target Considerations and Future Directions Aug 5, 2021
- Surgical Management for Dystonia: Efficacy of Deep Brain Stimulation in the Long Term Aug 3, 2021
- Prognostic value of brain tissues’ volumes in patients with essential tremor treated with MRgFUS thalamotomy Aug 2, 2021
- Directed stimulation of the dentato-rubro-thalamic tract for deep brain stimulation in essential tremor: a blinded clinical trial Aug 2, 2021
- Habituation After Deep Brain Stimulation in Tremor Syndromes: Prevalence, Risk Factors and Long-Term Outcomes Aug 2, 2021
- Cerebellar Oscillations in Familial and Sporadic Essential Tremor Aug 2, 2021
- NOTCH2NLC-related repeat expansion disorders: an expanding group of neurodegenerative disorders Jul 31, 2021
- The diagnostic value of clinical neurophysiology in hyperkinetic movement disorders: A systematic review Jul 31, 2021
- Deep brain stimulation programming strategies: segmented leads, independent current sources, and future technology Jul 30, 2021
- Cervical vestibular-evoked myogenic potentials in patients with essential tremor Jul 29, 2021
- How neuropsychiatric comorbidity, modulatory indication, demographics, and other factors impact deep brain stimulation inpatient outcomes in the United States: A population-based study of 27,956 patients Jul 26, 2021
- Tremor Syndromes: An Updated Review Jul 25, 2021
- Global efficiency of the motor network is decreased in Parkinson’s disease in comparison with essential tremor and healthy controls Jul 24, 2021
- Is It Possible to Save the Deep Brain Stimulation Hardware when Presenting with Wound Dehiscence or Hardware Infection? Jul 21, 2021
- Bilateral Focused Ultrasound Thalamotomy for Essential Tremor (BEST-FUS Phase 2 Trial) Jul 20, 2021
- Primary Writing Tremor: Current Concepts Jul 17, 2021
- Neurophysiological biomarkers to optimize deep brain stimulation in movement disorders Jul 15, 2021
- The evaluation of the swallow tail sign in patients with parkinsonism and gait disorders Jul 14, 2021
- Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor: A 2-Year Outcome Study of Chinese People Jul 14, 2021
- How Common is Essential Tremor? Update on the Worldwide Prevalence of Essential Tremor Jul 9, 2021
- Neuromodulation Approaches in Parkinson’s Disease Using Deep Brain Stimulation and Transcranial Magnetic Stimulation Jul 5, 2021
- Novel Presentation of Aphasia and Tremor in Immune-Mediated Necrotizing Myopathy Jul 4, 2021
- Synaptic effects of ethanol on striatal circuitry: therapeutic implications for dystonia Jul 3, 2021
- Brain MRI-guided focused ultrasound conceptualised as a tool for brain network intervention Jul 2, 2021
- Mild cognitive impairment, dementia and risk of mortality in essential tremor: A longitudinal prospective study of elders Jul 1, 2021
- Predictors of thermal response and lesion size in patients undergoing magnetic resonance-guided focused ultrasound thalamotomy Jun 30, 2021
- Gamma Knife Thalamotomy for a Medically Refractory Tremors: Longitudinal Evaluation of Clinical Effects and MRI Response Patterns Jun 30, 2021
- Determining an efficient deep brain stimulation target in essential tremor – Cohort study and review of the literature Jun 29, 2021
- White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly Jun 27, 2021
- Correction: Can Plasma alpha-Synuclein Help Us to Differentiate Parkinson’s Disease from Essential Tremor? Jun 25, 2021
- Finding New Ways To Treat Tremors Jun 22, 2021
- Nonlinear irregularities in Parkinson’s disease tremor and essential tremor Jun 17, 2021
- Chronic clicking tinnitus due to palatal tremor: essential or secondary? Jun 17, 2021
- MRI Guided Focused Ultrasound-Mediated Delivery of Therapeutic Cells to the Brain: A Review of the State-of-the-Art Methodology and Future Applications Jun 17, 2021
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review Jun 16, 2021
- Corrigendum to: Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation Jun 11, 2021
- Early Deformation of Deep Brain Stimulation Electrodes Following Surgical Implantation: Intracranial, Brain, and Electrode Mechanics Jun 11, 2021
- Wearable Devices for Assessment of Tremor Jun 10, 2021
- Voxel-Based Morphometry of Cerebellar Lobules in Essential Tremor Jun 9, 2021
- Stimulation-Induced Side Effects of Deep Brain Stimulation in the Ventralis Intermedius and Posterior Subthalamic Area for Essential Tremor Jun 9, 2021
- Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management Jun 7, 2021
- Behavioral Therapy for Tremor or Dystonia Affecting Voice in Speakers with Hyperkinetic Dysarthria: A Systematic Review Jun 7, 2021
- Radiofrequency Ablation for Movement Disorders: Risk Factors for Intracerebral Hemorrhage, a Retrospective Analysis Jun 7, 2021
- Tremor and Parkinsonism in Chromosomopathies – A Systematic Review May 31, 2021
- Spinocerebellar ataxia type 21 (TMEM240) with tremor and dystonia May 30, 2021
- Different effects of essential tremor and Parkinsonian tremor on multiscale dynamics of hand tremor May 28, 2021
- Wearable Peripheral Electrical Stimulation Devices for the Reduction of Essential Tremor: A Review May 28, 2021
- Can Plasma alpha-Synuclein Help Us to Differentiate Parkinson’s Disease from Essential Tremor? May 28, 2021
- Genomic Markers for Essential Tremor May 27, 2021
- The Magnetic Resonance Imaging (MRI)-Directed Implantable Guide Tube Technique: Accuracy and Applications in Deep Brain Stimulation May 24, 2021
- Technical and operative factors affecting magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: experience from 250 treatments May 20, 2021
- Thalamic but Not Subthalamic Neuromodulation Simplifies Word Use in Spontaneous Language May 19, 2021
- Physical Activity as a Predictor of Cognitive Decline in an Elderly Essential Tremor Cohort: A Prospective, Longitudinal Study May 19, 2021
- Neuroimaging Assessment of Nigrosome 1 with a Multiecho Gre Magnetic Resonance Sequence in the Differentiation Between Parkinsons Disease from Essential Tremor and Healthy Individuals May 18, 2021
- The Distribution of Skull Score and Skull Density Ratio in Tremor Patients for MR-Guided Focused Ultrasound Thalamotomy May 16, 2021
Clinical Trials
- New Stereotactic Frame System for Neurosurgery Oct 14, 2021
- ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 16, 2021
- Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 8, 2021
- Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor Sep 8, 2021
- ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders Sep 8, 2021
- [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson’s Diseases and Essential Tremor Sep 5, 2021
- A Study to Evaluate the Effectiveness and Safety of ExAblate MRgFUS on Essential Tremor Sep 5, 2021
- Cyclic Deep Brain Stimulation in Essential Tremor Sep 2, 2021
- Cerebello-thalamo-cortical Coupling in Essential Tremor Aug 30, 2021
- A Clinical Trial of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- A Clinical Trial of 3 Doses of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives Aug 13, 2021
- Responsive Deep Brain Stimulator for Essential Tremor Aug 12, 2021
- Cortical-Basal Ganglia Speech Networks Aug 9, 2021
- Deep braIn Stimulation for Tremor TractographIC Versus Traditional Jul 28, 2021
- Sensory-specific Peripheral Stimulation for Tremor Management Jul 21, 2021
- Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity Jul 16, 2021
- Effects of Stimulation Patterns of Deep Brain Stimulation Jul 2, 2021
- Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson’s Disease and Tremor May 18, 2021
- Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor May 11, 2021
- UPDATED: Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Directional Versus Nondirectional DBS for ET Apr 2, 2021
- Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
- Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
- Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
- RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
- Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
- A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
- Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
- Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
- A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
- Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
- A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
- Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
- Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
- Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
- A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021
- Wearable Sensor for Responsive DBS for ET Jan 14, 2021
- Optimization of VIM Targeting in Essential Tremor Surgery Jan 12, 2021
- A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Dec 23, 2020
- Trial of Cannabis for Essential Tremor Dec 21, 2020
- Mapping the Target for the MRgFUS Treatment of Tremor Dec 10, 2020
- Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings Dec 8, 2020
- Deep Brain Stimulation Therapy in Movement Disorders Nov 17, 2020
- Physiology, Imaging and Modeling of Essential Tremor Nov 12, 2020
- Demand-driven Management of Essential Tremor Nov 5, 2020
- Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? Oct 30, 2020
- Masotherapy With Neural Tension in Patients With Parkinson’s Disease Oct 23, 2020
- A Clinical Study to Evaluate CAD-1883 in Essential Tremor Oct 14, 2020
- Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
- Alternating Current Stimulation for Essential Tremor Sep 2, 2020
- Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
- Trial of Cannabis for Essential Tremor May 29, 2020
