This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects
Last updated: 2 years ago
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News
- Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
- First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
- Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
- Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
- INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
- New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
- New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
- Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
- Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
- New radiation therapy shows promise for treating essential tremor Jun 14, 2019
Research
- The Italian tremor Network (TITAN): rationale, design and preliminary findings May 23, 2022
- Essential tremor impairs the ability to suppress involuntary action impulses May 13, 2022
- The differences in clinical characteristics and natural history between essential tremor and essential tremor plus May 10, 2022
- Sweet spots of standard and directional leads in patients with refractory essential tremor: white matter pathways associated with maximal tremor improvement May 6, 2022
- Cognitive functioning in essential tremor without dementia: a clinical and imaging study May 4, 2022
- Short pulse and directional thalamic deep brain stimulation have differential effects in parkinsonian and essential tremor May 4, 2022
- Intensification of an Essential Tremor by SARS-CoV-2 May 2, 2022
- Reply to “Intensification of an Essential Tremor by SARS-CoV-2” May 2, 2022
- Awake Deep Brain Stimulation Surgery Without Intraoperative Imaging Is Accurate and Effective: A Case Series Apr 29, 2022
- How childhood trauma and emotions influence essential tremor and its severity in Sakarya Province Apr 29, 2022
- Evaluation of DBS Timeline in Movement Disorders: A Comparison Between Genders Apr 28, 2022
- Quantitative behavioral models for high-resolution measurement and characterization of tremor in rodents Apr 26, 2022
- Directional stimulation improves stimulation-induced dysgeusia in DBS for essential tremor Apr 25, 2022
- Epidemiology of Pediatric Essential Tremor in the United States: A Systematic Literature Review from 2010 to 2020 Apr 19, 2022
- Probing responses to deep brain stimulation with functional magnetic resonance imaging Apr 18, 2022
- Complications After Deep Brain Stimulation: A 21-Year Experience in 426 Patients Apr 7, 2022
- Depressive symptoms predict memory decline in Essential Tremor Apr 6, 2022
- Spectrum of movement disorders: Experience of a one and half year of existence of the first specialized center in Senegal Apr 6, 2022
- Phytohormone abscisic acid elicits positive effects on harmaline-induced cognitive and motor disturbances in a rat model of essential tremor Apr 4, 2022
- Connectomic analysis of unilateral dual-lead thalamic deep brain stimulation for treatment of multiple sclerosis tremor Mar 31, 2022
- Converging on a Neuromodulation Target for Tremor Mar 31, 2022
- Essential tremor and cognitive impairment: who, how, and why Mar 31, 2022
- Ventral Intermediate Nucleus of the Thalamus versus Posterior Subthalamic Area: Network Meta-Analysis of DBS Target Site Efficacy for Essential Tremor Mar 29, 2022
- Neurotrophins as Therapeutic Agents for Parkinson’s Disease; New Chances From Focused Ultrasound? Mar 29, 2022
- Wearable sensors during drawing tasks to measure the severity of essential tremor Mar 28, 2022
- Uncovering Essential Tremor Genetics: The Promise of Long-Read Sequencing Mar 28, 2022
- Vitamin D Receptor and Binding Protein Gene Variants in Patients with Essential Tremor Mar 23, 2022
- Treatment Patterns in Essential Tremor: A Retrospective Analysis Mar 23, 2022
- Identification and Classification of Parkinsonian and Essential Tremors for Diagnosis Using Machine Learning Algorithms Mar 22, 2022
- Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis Mar 16, 2022
- Gamma Knife stereotactic radiosurgery as a treatment for essential and parkinsonian tremor: long-term experience Mar 16, 2022
- Reliable cognitive change following unilateral deep brain stimulation in essential tremor Mar 15, 2022
- Botulinum Toxin for Essential Tremor and Hands Tremor in the Neurological Diseases: A Meta-Analysis of Randomized Controlled Trials Mar 10, 2022
- Online tracking of the phase difference between neural drives to antagonist muscle pairs in essential tremor patients Mar 10, 2022
- Disrupted Brain Functional Network Topology in Essential Tremor Patients With Poor Sleep Quality Mar 10, 2022
- Thalamic local field potentials recorded using the deep brain stimulation pulse generator Mar 9, 2022
- Objective quantification of the severity of postural tremor based on kinematic parameters: A multi-sensory fusion study Mar 9, 2022
- Translational Pharmacology of PRAX-944, a Novel T-Type Calcium Channel Blocker in Development for the Treatment of Essential Tremor Mar 7, 2022
- Bayesian Interpretation of Essential Tremor Plus Mar 7, 2022
- Motion characteristics of subclinical tremors in Parkinson’s disease and normal subjects Mar 7, 2022
- Combined multivariate pattern analysis with frequency-dependent intrinsic brain activity to identify essential tremor Mar 5, 2022
- Deep brain stimulation for the treatment of tremor Mar 4, 2022
- Neurological symptoms and disorders following electrical injury: A register-based matched cohort study Mar 2, 2022
- Effect of Public Interest in Magnetic Resonance Imaging-Guided Focused Ultrasound on Enrolment for Deep Brain Stimulation Mar 2, 2022
- Essential Tremor-Do We Have Better Therapeutics? A Review of Recent Advances and Future Directions Mar 2, 2022
- Distractibility predicts favourable response of functional tremor to transcranial magnetic stimulation: An electrophysiological study Mar 1, 2022
- Lateralized and region-specific thalamic processing of lexical status during reading aloud Mar 1, 2022
- Real-time classification of movement patterns of tremor patients Feb 26, 2022
- Essential tremor: Clinical perspectives and pathophysiology Feb 22, 2022
- Tremor rating scales and laboratory tools for assessing tremor Feb 21, 2022
- Remote measurement and home monitoring of tremor Feb 21, 2022
- Clinical features, pathophysiology, treatment, and controversies of tremor in dystonia Feb 21, 2022
- Rare tremors and tremors occurring in other neurological disorders Feb 19, 2022
- Problems and controversies in tremor classification Feb 19, 2022
- Botulinum toxin for the treatment of tremor Feb 19, 2022
- Improving functional disability in patients with tremor: A clinical perspective of the efficacies, considerations, and challenges of assistive technology Feb 19, 2022
- Non-invasive electrical stimulation of peripheral nerves for the management of tremor Feb 19, 2022
- Medications used to treat tremors Feb 19, 2022
- Focused ultrasound and other lesioning in the treatment of tremor Feb 19, 2022
- Drug-induced tremor, clinical features, diagnostic approach and management Feb 19, 2022
- The MDS consensus tremor classification: The best way to classify patients with tremor at present Feb 19, 2022
- Editorial: Tremors Feb 19, 2022
- Differentiating Parkinson’s Disease from Essential Tremor Using Transcranial Sonography: A Systematic Review and Meta-Analysis Feb 18, 2022
- Magnetic Resonance Image Guided Focused Ultrasound Thalamotomy. A Single Center Experience With 160 Procedures Feb 17, 2022
- Personalizing deep brain stimulation using advanced imaging sequences Feb 14, 2022
- Probabilistic mapping reveals optimal stimulation site in essential tremor Feb 12, 2022
- Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor Under General Anesthesia: Technical Note Feb 11, 2022
- Deep Brain Stimulation for Arm Tremor: A Randomized Trial Comparing Two Targets Feb 11, 2022
- Milestones in Tremor Research: 10 Years Later Feb 2, 2022
- Trans-Spinal Focused Ultrasound Stimulation Selectively Modulates Descending Motor Pathway Feb 2, 2022
- Reclassification of patients with tremor syndrome and comparisons of essential tremor and essential tremor-plus patients Jan 30, 2022
- Patients’ self-assessment of essential tremor severity by a validated scale: A useful tool in telemedicine? Jan 29, 2022
- Electrophysiological testing aids the diagnosis of tremor and myoclonus in clinically challenging patients Jan 29, 2022
- Anodic and symmetric biphasic pulses enlarge the therapeutic window in deep brain stimulation for essential tremor Jan 29, 2022
- Serum NFL discriminates Parkinson disease from essential tremor and reflect motor and cognition severity Jan 27, 2022
- Chronic encapsulated expanding hematoma after gamma knife thalamotomy for essential tremor Jan 25, 2022
- Eye Movement Disorders in Movement Disorders Jan 25, 2022
- The clinical and electrophysiological investigation of tremor Jan 24, 2022
- Balance and cognitive impairments are prevalent and correlated with age in presurgical patients with essential tremor Jan 23, 2022
- Movement disorders Jan 21, 2022
- Technical Comparison of Treatment Efficiency of Magnetic Resonance-Guided Focused Ultrasound Thalamotomy and Pallidotomy in Skull Density Ratio-Matched Patient Cohorts Jan 20, 2022
- Cerebellar tDCS as Therapy for Cerebellar Ataxias Jan 20, 2022
- Magnetic Resonance Imaging-Guided Focused Ultrasound Thalamotomy in Spinocerebellar Ataxia Type 12 Jan 20, 2022
- Tractography-Based Surgical Targeting for Thalamic Deep Brain Stimulation: A Comparison of Probabilistic vs Deterministic Fiber Tracking of the Dentato-Rubro-Thalamic Tract Jan 19, 2022
- Essential palatal tremor Jan 17, 2022
- Evaluation of rest tremor in different positions in Parkinson’s disease and essential tremor plus Jan 15, 2022
- The Fast Gray Matter Acquisition T1 Inversion Recovery Sequence in Deep Brain Stimulation: Introducing the Rubral Wing for Dentato-Rubro-Thalamic Tract Depiction and Tremor Control Jan 14, 2022
- Commentary: Feasibility of Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor in the Setting of Prior Craniotomy Jan 14, 2022
- Effect of Deep Brain Stimulation on Cerebellar Tremor Compared to Non-Cerebellar Tremor Using a Wearable Device in a Patient With Multiple Sclerosis: Case Report Jan 12, 2022
- α 6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials Jan 11, 2022
- Treatment of Essential Vocal Tremor: A Scoping Review of Evidence-Based Therapeutic Modalities Jan 10, 2022
- Analyzing the Effects of Parameters for Tremor Modulation via Phase-Locked Electrical Stimulation on a Peripheral Nerve Jan 9, 2022
- Worsening of Essential Tremor After SARS-CoV-2 Infection Jan 5, 2022
- Association of Essential Tremor With Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis Jan 4, 2022
- Quantifying the impact of upper limb tremor on the quality of life of people with multiple sclerosis: a comparison between the QUEST and MSIS-29 scales Jan 3, 2022
- Correction: Petry-Schmelzer et al. Selecting the Most Effective DBS Contact in Essential Tremor Patients Based on Individual Tractography. Brain Sci. 2020, 10, 1015 Jan 3, 2022
- Primidone Intolerance in Essential tremor: Is it More than Just Age? Dec 31, 2021
- A Non-Invasive IR Sensor Technique to Differentiate Parkinson’s Disease from Other Neurological Disorders Using Autonomic Dysfunction as Diagnostic Criterion Dec 30, 2021
- Analysis of circulating metabolites to differentiate Parkinson’s disease and essential tremor Dec 28, 2021
- Morphological and morphometric changes in the Purkinje cells of patients with essential tremor Dec 22, 2021
Clinical Trials
- The Swedish Essential Tremor (SWEET) Trial May 25, 2022
- A Clinical Trial of PRAX-114 in Participants With Essential Tremor May 24, 2022
- A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor May 9, 2022
- Neurophysiologic Assessment of ET Patients Treated by Vim DBS May 5, 2022
- Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia Apr 7, 2022
- Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation Apr 4, 2022
- Efficacy, Safety, and Pharmacokinetics of ES-481 in Adult Patients With Essential Tremors Feb 10, 2022
- Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor Jan 31, 2022
- Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation Jan 28, 2022
- Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma Jan 28, 2022
- Interphase Gap in Biphasic Stimulation in DBS for ET Jan 5, 2022
- Study to Evaluate SAGE-324 in Participants With Essential Tremors Dec 29, 2021
- Repetitive Transcranial Magnetic Stimulation in Essential Tremors Patients Dec 15, 2021
- A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET) Nov 17, 2021
- The Effects of Vibrotactile Stimulation in Patients With Movement Disorders Nov 4, 2021
- Neurofeedback Using Implanted Deep Brain Stimulation Electrodes Nov 1, 2021
- DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET) Oct 27, 2021
- Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001) Oct 22, 2021
- A Phase 2 RCT Study of CX-8998 for Essential Tremor Oct 22, 2021
- New Stereotactic Frame System for Neurosurgery Oct 14, 2021
- ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 16, 2021
- Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 8, 2021
- Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor Sep 8, 2021
- ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders Sep 8, 2021
- [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson’s Diseases and Essential Tremor Sep 5, 2021
- A Study to Evaluate the Effectiveness and Safety of ExAblate MRgFUS on Essential Tremor Sep 5, 2021
- Cyclic Deep Brain Stimulation in Essential Tremor Sep 2, 2021
- Cerebello-thalamo-cortical Coupling in Essential Tremor Aug 30, 2021
- A Clinical Trial of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- A Clinical Trial of 3 Doses of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives Aug 13, 2021
- Responsive Deep Brain Stimulator for Essential Tremor Aug 12, 2021
- Cortical-Basal Ganglia Speech Networks Aug 9, 2021
- Deep braIn Stimulation for Tremor TractographIC Versus Traditional Jul 28, 2021
- Sensory-specific Peripheral Stimulation for Tremor Management Jul 21, 2021
- Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity Jul 16, 2021
- Effects of Stimulation Patterns of Deep Brain Stimulation Jul 2, 2021
- Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson’s Disease and Tremor May 18, 2021
- Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor May 11, 2021
- UPDATED: Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Directional Versus Nondirectional DBS for ET Apr 2, 2021
- Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
- Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
- Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
- RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
- Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
- A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
- Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
- Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
- A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
- Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
- A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
- Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
- Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
- Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
- A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021
- Wearable Sensor for Responsive DBS for ET Jan 14, 2021
- Optimization of VIM Targeting in Essential Tremor Surgery Jan 12, 2021
- A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Dec 23, 2020
- Trial of Cannabis for Essential Tremor Dec 21, 2020
- Mapping the Target for the MRgFUS Treatment of Tremor Dec 10, 2020
- Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings Dec 8, 2020
- Deep Brain Stimulation Therapy in Movement Disorders Nov 17, 2020
- Physiology, Imaging and Modeling of Essential Tremor Nov 12, 2020
- Demand-driven Management of Essential Tremor Nov 5, 2020
- Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? Oct 30, 2020
- Masotherapy With Neural Tension in Patients With Parkinson’s Disease Oct 23, 2020
- A Clinical Study to Evaluate CAD-1883 in Essential Tremor Oct 14, 2020
- Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
- Alternating Current Stimulation for Essential Tremor Sep 2, 2020
- Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
- Trial of Cannabis for Essential Tremor May 29, 2020
