This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects
Last updated: 6 months ago
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News
- Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
- First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
- Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
- Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
- INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
- New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
- New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
- Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
- Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
- New radiation therapy shows promise for treating essential tremor Jun 14, 2019
Research
- Clinical Features of Essential Voice Tremor and Associations with Tremor Severity and Response to Octanoic Acid Treatment Apr 17, 2021
- What might cervical vestibular-evoked myogenic potential abnormalities mean in essential tremor? Apr 15, 2021
- Ventralis oralis anterior (Voa) deep brain stimulation plus Gamma Knife thalamotomy in an elderly patient with essential tremor: A case report Apr 13, 2021
- Agmatine has beneficial effect on harmaline-induced essential tremor in rat Apr 7, 2021
- Optimizing deep brain stimulation based on isostable amplitude in essential tremor patient models Apr 6, 2021
- Lateralized Effect of Thalamic Deep Brain Stimulation Location on Verbal Abstraction Apr 5, 2021
- The Signature of Primary Writing Tremor Is Dystonic Mar 30, 2021
- Fatigue in hypokinetic, hyperkinetic, and functional movement disorders Mar 29, 2021
- The Brain Connectome after Gamma Knife Radiosurgery of the Ventro-Intermediate Nucleus for Tremor: Marseille-Lausanne Radiobiology Study Protocol Mar 29, 2021
- Disrupted brain gray matter networks in drug-naive participants with essential tremor Mar 29, 2021
- Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson’s Disease in a Movement Disorders Clinic Mar 29, 2021
- Assessment of Motor Dysfunction with Virtual Reality in Patients Undergoing [123 I]FP-CIT SPECT/CT Brain Imaging Mar 26, 2021
- Abnormalities of intrinsic brain activity in essential tremor: A meta-analysis of resting-state functional imaging Mar 26, 2021
- The Essential Tremors: Evolving Concepts of a Family of Diseases Mar 25, 2021
- Essential Tremor versus “ET-plus”: A Detailed Postmortem Study of Cerebellar Pathology Mar 25, 2021
- A Phase 2 Proof-of-Concept, Randomized, Placebo-Controlled Trial of CX-8998 in Essential Tremor Mar 25, 2021
- The Progression of Essential Tremors: Illustrative Videos Mar 24, 2021
- ‘Essential Tremor’ Phenotype in FMR1 Premutation/Gray Zone Sibling Series: Exploring Possible Genetic Modifiers Mar 23, 2021
- Anatomical texture patterns identify cerebellar distinctions between essential tremor and Parkinson’s disease Mar 23, 2021
- Sleep Disorders in Patients with Essential Tremor Mar 22, 2021
- Spinal astroglial cannabinoid receptors control pathological tremor Mar 18, 2021
- Directional Stimulation in Parkinson’s Disease and Essential Tremor: The Cleveland Clinic Experience Mar 17, 2021
- No evidence of iron deposition in essential tremor: a susceptibility-weighted imaging study Mar 15, 2021
- A Voxel-Wise Meta-Analysis on the Cerebellum in Essential Tremor Mar 14, 2021
- Increased structural connectivity of thalamic stimulation sites to motor cortex relates to tremor suppression Mar 13, 2021
- The Decline of Deep Brain Stimulation for Obsessive-Compulsive Disorder Following FDA Humanitarian Device Exemption Approval Mar 11, 2021
- Disrupted Brain Network Topology in Drug-naive Essential Tremor Patients with and Without Depression : A Resting State Functional Magnetic Resonance Imaging Study Mar 9, 2021
- Speech Function Following Deep Brain Stimulation of the Caudal Zona Incerta: Effects of Habitual and High-Amplitude Stimulation Mar 1, 2021
- Abnormal movements in hospitalized COVID-19 patients: A case series Feb 26, 2021
- Descriptive epidemiological study on patients with movement disorders, with emphasis on Parkinson’s disease Feb 24, 2021
- Clinical and Imaging Profile of Patients with Palatal Tremor Feb 18, 2021
- Peripheral electrical stimulation to reduce pathological tremor: a review Feb 17, 2021
- Cognitive subtypes in individuals with essential tremor seeking deep brain stimulation Feb 14, 2021
- Altered local and matrix functional connectivity in depressed essential tremor patients Feb 11, 2021
- Automatic Classification of Healthy Subjects and Patients With Essential Vocal Tremor Using Probabilistic Source-Filter Model Based Noise Robust Pitch Estimation Feb 10, 2021
- Quality of life in isolated dystonia: non-motor manifestations matter Feb 9, 2021
- Adoption of focused ultrasound thalamotomy for essential tremor: why so much fuss about FUS? Feb 9, 2021
- Clock-Drawing Tasks as Predictive Measurements for Disease Classification Among Patients With Parkinson’s Disease and Essential Tremor Feb 9, 2021
- Closed-Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials Feb 8, 2021
- Smell tests to distinguish Parkinson’s disease from other neurological disorders: a systematic review and meta-analysis Feb 6, 2021
- Voice Analysis with Machine Learning: One Step Closer to an Objective Diagnosis of Essential Tremor Feb 4, 2021
- Prescribing cascades and medications most frequently involved in pain therapy: a review Feb 1, 2021
- Bilateral Subdural Hygromas After Deep Brain Stimulation Implantation in the Setting of Unrecognized Intracranial Hypotension Jan 30, 2021
- A case of Anti-LGi-1 antibody positive autoimmune epilepsy following deep brain stimulator implantation for essential tremor Jan 30, 2021
- Development and Validation of a New Wearable Mobile Device for the Automated Detection of Resting Tremor in Parkinson’s Disease and Essential Tremor Jan 29, 2021
- The spiral axis: A comparison of unaffected first-degree relatives of essential tremor cases vs. controls Jan 28, 2021
- Non-motor symptoms in essential tremor, akinetic rigid and tremor-dominant subtypes of Parkinson’s disease Jan 27, 2021
- Increased Climbing Fiber Lateral Crossings on Purkinje Cell Dendrites in the Cerebellar Hemisphere in Essential Tremor Jan 26, 2021
- Orthostatic Hypotension in Elderly Patients with Essential Tremor Jan 21, 2021
- Commentary: Focused Ultrasound Thalamotomy for Refractory Essential Tremor: A Japanese Multicenter Single-Arm Study Jan 20, 2021
- Focused Ultrasound Thalamotomy for Refractory Essential Tremor: A Japanese Multicenter Single-Arm Study Jan 19, 2021
- Deep Brain Stimulation in Alzheimer’s Disease: Targeting the Nucleus Basalis of Meynert Jan 19, 2021
- Combination targeting of subthalamic nucleus and ventral intermediate thalamic nucleus with a single trajectory in deep brain stimulation for tremor-dominant Parkinson’s disease Jan 18, 2021
- Exploring Interrater Disagreement on Essential Tremor Using a Standardized Tremor Elements Assessment Jan 18, 2021
- A novel approach to differential diagnosis of Parkinson’s disease and essential tremor Jan 18, 2021
- DBS targeting for essential tremor using intersectional dentato-rubro-thalamic tractography and direct proton density visualization of the VIM: technical note on 2 cases Jan 14, 2021
- Botulinum Toxin Monotherapy for the Treatment of Essential Tremor: Life Quality Effect Jan 14, 2021
- A single oral dose of cannabidiol did not reduce upper limb tremor in patients with essential tremor Jan 13, 2021
- Objective Detection of Microtremors in Netrin-G2 Knockout Mice Jan 13, 2021
- Descriptive epidemiological study on patients with movement disorders, with emphasis on Parkinson’s disease Jan 13, 2021
- Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence Jan 13, 2021
- Essential tremor and cognitive decline Jan 9, 2021
- Brain rhythm bursts are enhanced by multiplicative noise Jan 8, 2021
- Essential Palatal Tremor Following an Upper Respiratory Tract Infection: A Case Report Jan 6, 2021
- On the use of histograms of oriented gradients for tremor detection from sinusoidal and spiral handwritten drawings of people with Parkinson’s disease Jan 6, 2021
- Test-retest reproducibility of dopamine transporter density measured with [(18)F]FP-CIT PET in patients with essential tremor and Parkinson’s disease Jan 2, 2021
- Novel Botulinum Toxin Injection Protocols for Parkinson Tremor and Essential Tremor – the Yale Technique and Sensor-Based Kinematics Procedure for Safe and Effective Treatment Dec 31, 2020
- Adductor Spasmodic Dysphonia Improves with Bilateral Thalamic Deep Brain Stimulation: Report of 3 Cases Done Asleep and Review of Literature Dec 31, 2020
- Progression to dementia in patients with essential tremor Dec 30, 2020
- Neuropharmacological potentials of β-Carboline Alkaloids for neuropsychiatric disorders – A review Dec 24, 2020
- Does Essential Tremor Alter the Axonal Excitability Properties of Lower Motor Neurons? Dec 24, 2020
- Engineering Botulinum Neurotoxins for Enhanced Therapeutic Applications and Vaccine Development Dec 22, 2020
- Errata to “Quantifying Tremor in Essential Tremor Using Inertial Sensors Validation of an Algorithm” Dec 22, 2020
- The relationship between serum interleukin-1beta, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-alpha levels and clinical features in essential tremor Dec 21, 2020
- Tolerability and Efficacy of Customized IncobotulinumtoxinA Injections for Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Study Dec 21, 2020
- Selecting the Most Effective DBS Contact in Essential Tremor Patients Based on Individual Tractography Dec 20, 2020
- The development of an implantable deep brain stimulation device with simultaneous chronic electrophysiological recording and stimulation in humans Dec 16, 2020
- Brain Metabolic Changes with Longitudinal Transcutaneous Afferent Patterned Stimulation in Essential Tremor Subjects Dec 16, 2020
- Technology Integration Methods for Bi-directional Brain-computer Interfaces and XR-based Interventions Dec 14, 2020
- DyNeuMo Mk-2: An Investigational Circadian-Locked Neuromodulator with Responsive Stimulation for Applied Chronobiology Dec 14, 2020
- Thalamic Deep Brain Stimulation in Essential Tremor Plus Is as Effective as in Essential Tremor Dec 13, 2020
- Cognitive Outcomes for Essential Tremor Patients Selected for Thalamic Deep Brain Stimulation Surgery Through Interdisciplinary Evaluations Dec 10, 2020
- Association between positive history of essential tremor and disease progression in patients with Parkinson’s disease Dec 10, 2020
- Analysis of neural clusters due to deep brain stimulation pulses Dec 9, 2020
- TNR Gene Mutation in Familial Parkinson’s Disease: Possible Implications for Essential Tremor Dec 3, 2020
- Dentate nucleus stimulation for essential tremor Dec 3, 2020
- Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor Dec 2, 2020
- Calpain activity in plasma of patients with essential tremor and Parkinson’s disease: a pilot study Dec 1, 2020
- O-Arm Stereotactic Imaging in Deep Brain Stimulation Surgery Workflow: A Utility and Cost-Effectiveness Analysis Dec 1, 2020
- Deep-Brain Stimulation for Essential Tremor and Other Tremor Syndromes: A Narrative Review of Current Targets and Clinical Outcomes Dec 1, 2020
- Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains Dec 1, 2020
- Technology of deep brain stimulation: current status and future directions Nov 26, 2020
- “Benign” tremor? A serial case report of 2.5 year progression from mild cognitive impairment to amnestic dementia following deep brain stimulator placement for essential tremor Nov 24, 2020
- Comparative Performance of 99mTc-TRODAT-1 SPECT/CT and 18F-FDOPA PET/CT Imaging in Patients With Parkinson’s Disease, Parkinson-Plus Syndrome, and Essential Tremor Nov 24, 2020
- Exome-wide rare variant analysis in familial essential tremor Nov 24, 2020
- Endurance of Short Pulse Width Thalamic Stimulation Efficacy in Intention Tremor Nov 23, 2020
- Imaging Tremor Quantification for Neurological Disease Diagnosis Nov 22, 2020
- Response to “Bipolar Directional Deep Brain Stimulation in Essential and Parkinsonian Tremor”-A Technology Underutilized Nov 22, 2020
- Reply: Assessing the NOTCH2NLC GGC expansion in essential tremor patients from eastern China Nov 17, 2020
- Assessing the NOTCH2NLC GGC expansion in essential tremor patients from eastern China Nov 17, 2020
Clinical Trials
- Directional Versus Nondirectional DBS for ET Apr 2, 2021
- Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
- Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
- Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
- RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
- Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
- A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
- Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
- Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
- A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
- Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
- A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
- Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
- Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
- Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
- A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021
- Wearable Sensor for Responsive DBS for ET Jan 14, 2021
- Optimization of VIM Targeting in Essential Tremor Surgery Jan 12, 2021
- A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Dec 23, 2020
- Trial of Cannabis for Essential Tremor Dec 21, 2020
- Mapping the Target for the MRgFUS Treatment of Tremor Dec 10, 2020
- Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings Dec 8, 2020
- Deep Brain Stimulation Therapy in Movement Disorders Nov 17, 2020
- Physiology, Imaging and Modeling of Essential Tremor Nov 12, 2020
- Demand-driven Management of Essential Tremor Nov 5, 2020
- Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? Oct 30, 2020
- Masotherapy With Neural Tension in Patients With Parkinson’s Disease Oct 23, 2020
- A Clinical Study to Evaluate CAD-1883 in Essential Tremor Oct 14, 2020
- Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
- Alternating Current Stimulation for Essential Tremor Sep 2, 2020
- Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
- Trial of Cannabis for Essential Tremor May 29, 2020
