This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects
Last updated: 2 years ago
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News
- Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
- First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
- Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
- Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
- INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
- New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
- New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
- Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
- Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
- New radiation therapy shows promise for treating essential tremor Jun 14, 2019
Research
- Locus coeruleus degeneration and cerebellar gray matter changes in essential tremor Oct 4, 2022
- Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology Sep 29, 2022
- Prediction of Pathological Tremor Signals Using Long Short-Term Memory Neural Networks Sep 28, 2022
- Functional connectivity of the cortico-subcortical sensorimotor loop is modulated by the severity of nigrostriatal dopaminergic denervation in Parkinson’s Disease Sep 28, 2022
- Noradrenergic Pathway to the Cerebellum: the Study Must Go On Sep 22, 2022
- The Cost-Effectiveness of unilateral magnetic Resonance-Guided focused ultrasound in comparison to unilateral deep brain stimulation for the treatment of medically refractory essential tremor in England Sep 20, 2022
- Challenging functional connectivity data: machine learning application on essential tremor recognition Sep 19, 2022
- Epicranial Direct Current Stimulation Suppresses Harmaline Tremor in Rats Sep 15, 2022
- Clinical Features and Reclassification of Essential Tremor with NOTCH2NLC GGC Repeat Expansions based on a long-term follow-up Sep 10, 2022
- Visuomotor Adaptation Deficits in Patients with Essential Tremor Sep 9, 2022
- Treatment-Specific Network Modulation of MRI-Guided Focused Ultrasound Thalamotomy in Essential Tremor : Modulation of ET-Related Network by MRgFUS Thalamotomy Sep 9, 2022
- Does Head Tremor Predict Postural Instability After Bilateral Thalamic Stimulation in Essential Tremor? Sep 9, 2022
- A Wearable In-home Tremor Assessment System via Virtual Reality Environment for the Activities in Daily Lives (ADLs) Sep 8, 2022
- Analysis of GIPC1 CGG repeat expansions in essential tremor Sep 7, 2022
- Physiological Recordings of the Cerebellum in Movement Disorders Sep 6, 2022
- Real-World Evidence of Transcutaneous Afferent Patterned Stimulation for Essential Tremor Sep 1, 2022
- Case report – Asterixis Post High Frequency Focused-Ultrasound Thalamotomy Aug 30, 2022
- Simultaneous Botox and Augmentation Injection Laryngoplasty in Patients With Adductor Spasmodic Dysphonia (ASD) and Tremor Aug 29, 2022
- A Bayesian approach to Essential Tremor plus: A preliminary analysis of the TITAN cohort Aug 28, 2022
- Patient-Reported Outcomes and Predictive Factors following Focused Ultrasound Thalamotomy for Essential Tremor Aug 26, 2022
- Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson’s disease and essential tremor Aug 26, 2022
- The Effect of Cerebellar rTMS on Modulating Motor Dysfunction in Neurological Disorders: a Systematic Review Aug 26, 2022
- Prospective, longitudinal analysis of medication use in a cohort of elderly essential tremor cases Aug 23, 2022
- Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor Aug 23, 2022
- Thalamo-cortical network is associated with harmaline-induced tremor in rodent model Aug 22, 2022
- Ipsilateral and axial tremor response to focused ultrasound thalamotomy for essential tremor: clinical outcomes and probabilistic mapping Aug 22, 2022
- Cutoff values for the best management strategy for magnetic resonance-guided focused ultrasound ablation for essential tremor Aug 19, 2022
- Real-World Longitudinal Experience of Botulinum Toxin Therapy for Parkinson and Essential Tremor Aug 17, 2022
- Probabilistic maps for deep brain stimulation – Impact of methodological differences Aug 17, 2022
- Robot-Assisted Deep Brain Stimulation: High Accuracy and Streamlined Workflow Aug 16, 2022
- Multiple Comorbidities, Psychiatric Disorders, Healthcare Resource Utilization and Costs Among Adults with Essential Tremor: A Retrospective Observational Study in a Large US Commercially Insured and Medicare Advantage Population Aug 15, 2022
- Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository Aug 11, 2022
- Unravelling delayed therapy escape after thalamic deep brain stimulation for essential tremor? – Additional clinical and neuroimaging evidence Aug 10, 2022
- Closing the loop: Novel quantitative fMRI approach for manipulation of the sensorimotor loop in tremor Aug 10, 2022
- Essential tremor-Parkinson’s disease syndrome: clinical characteristics and subtypes using cluster analysis Aug 8, 2022
- Lack of Familial Aggregation of the “Essential-Tremor-Plus” Phenotype in Familial Essential Tremor Aug 8, 2022
- Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results Aug 5, 2022
- Sex and gender differences in movement disorders: Parkinson’s disease, essential tremor, dystonia and chorea Aug 5, 2022
- Specific gut microbiota alterations in essential tremor and its difference from Parkinson’s disease Aug 4, 2022
- Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies Aug 4, 2022
- Transcriptomic effects of propranolol and primidone converge on molecular pathways relevant to essential tremor Aug 4, 2022
- A standardized accelerometry method for characterizing tremor: Application and validation in an ageing population with postural and action tremor Aug 3, 2022
- Automated deep brain stimulation programming with safety constraints for tremor suppression in patients with Parkinson’s Disease and essential tremor Aug 3, 2022
- Tremor evaluation using smartphone accelerometry in standardized settings Jul 31, 2022
- Distribution of rest tremor in patients with Essential Tremor: Does it lateralize with simple kinetic, postural, or intention tremors? Jul 31, 2022
- EMD-based data augmentation method applied to handwriting data for the diagnosis of Essential Tremor using LSTM networks Jul 30, 2022
- Cerebello-Thalamo-Cortical Network Dynamics in the Harmaline Rodent Model of Essential Tremor Jul 27, 2022
- Differences in intrinsic functional networks in patients with essential tremor who had good and poor long-term responses after thalamotomy performed using MR-guided ultrasound Jul 22, 2022
- Essential tremor patients experience significant burden beyond tremor: A systematic literature review Jul 22, 2022
- Sleep Dysfunction in Movement Disorders: a Window to the Disease Biology Jul 22, 2022
- Are smartphones and machine learning enough to diagnose tremor? Jul 21, 2022
- Cerebellar voxel-based morphometry in essential tremor Jul 19, 2022
- Non-motor features of essential tremor with midline distribution Jul 18, 2022
- Distribution of tremorogenic activity among the major superficial muscles of the upper limb in persons with Essential tremor Jul 16, 2022
- Brain Connectomics Jul 14, 2022
- Neurobiological effects of deep brain stimulation: A systematic review of molecular brain imaging studies Jul 12, 2022
- Machine learning aided classification of tremor in multiple sclerosis Jul 11, 2022
- Comparison of the impact of skull density ratio with alternative skull metrics on magnetic resonance-guided focused ultrasound thalamotomy for tremor Jul 8, 2022
- Differences in clinical manifestations of late-onset, compared to earlier-onset essential tremor: A scoping review Jul 8, 2022
- Structural connectivity alterations in the motor network of patients with scans without evidence of dopaminergic deficit (SWEDD) Jul 6, 2022
- Deep brain stimulation of the ventrointermediate nucleus of the thalamus to treat essential tremor improves motor sequence learning Jul 6, 2022
- Connecting tremors – a circuits perspective Jul 5, 2022
- Utility of postoperative imaging software on DBS targeting in patients with movement disorders Jul 1, 2022
- New horizons in late-onset essential tremor: a pre-cognitive biomarker of dementia? Jul 1, 2022
- Suppression of Axial Tremor by Deep Brain Stimulation in Patients with Essential Tremor: Effects on Gait and Balance Measures Jul 1, 2022
- Long-Term Clinical Experience with Directional Deep Brain Stimulation Programming: A Retrospective Review Jul 1, 2022
- Decreasing the Symptoms of Essential Tremor With Medical Painting Therapy Jun 29, 2022
- What could tell us posturography about balance in essential tremor? Jun 28, 2022
- Can the Montreal Cognitive Assessment and Mini-Mental State Examination detect cognitive decline in elderly patients with essential tremor? Jun 28, 2022
- Ipsilateral Effects of Unilateral Deep Brain Stimulation for Essential Tremor Jun 27, 2022
- Coherent Structural and Functional Network Changes after Thalamic Lesions in Essential Tremor Jun 23, 2022
- The future of pharmacotherapies for essential tremor: Enhancing GABA neurotransmission or reducing neuronal hyperexcitability? Jun 21, 2022
- How important is the inferior olive in essential tremor? An evolving story Jun 21, 2022
- Essential tremor: Is this an electrical or a degenerative disorder? Or is it both? Jun 21, 2022
- Essential tremor as a harbinger: What is the cognitive fallout of having essential tremor? Jun 21, 2022
- What’s in a Name? Nomenclature of essential tremor: Syndrome or family of diseases? Jun 21, 2022
- Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy Jun 19, 2022
- An Argument in Favor of Deep Brain Stimulation for Uncommon Movement Disorders: The Case for N-of-1 Trials in Holmes Tremor Jun 16, 2022
- Utility of routine surface electrophysiology to screen for functional tremor prior to surgical treatment of essential tremor Jun 16, 2022
- Motor features associated with cognition in non-demented individuals with essential tremor Jun 15, 2022
- Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor Jun 15, 2022
- Mediation of Tremor Control by the Decussating and Nondecussating Part of the Dentato-Rubro-Thalamic Tract in Deep Brain Stimulation in Essential Tremor: Which Part Should Be Stimulated? Jun 14, 2022
- Essential Tremor That is Difficult to Improve with Standard Medical Treatment-Suppression: Surgical Treatment of Tremor Jun 14, 2022
- Essential Tremor That is Difficult to Improve with Standard Medical Treatment-Suppression: Excluding Surgical Treatment Jun 14, 2022
- Rationale and Evidence for Peripheral Nerve Stimulation for Treating Essential Tremor Jun 14, 2022
- The Pharmacotherapeutic Landscape for Essential Tremor: Quantifying the Level of Unmet Need From a Patient and Epidemiologic Perspective Jun 13, 2022
- Which one is the superior target? A comparison and pooled analysis between posterior subthalamic area and ventral intermediate nucleus deep brain stimulation for essential tremor Jun 10, 2022
- Changes In The Cerebello-thalamo-cortical Network After MR-guided Focused Ultrasound Thalamotomy Jun 8, 2022
- Essential tremor plus rest tremor: current concepts and controversies Jun 7, 2022
- Overnight unilateral withdrawal of thalamic deep brain stimulation to identify reversibility of gait disturbances Jun 6, 2022
- Therapies, Research Funding, and Racial Diversity in Essential Tremor: A Systematic Review of the Literature Jun 2, 2022
- Longitudinal Progression of Essential Tremor: Do Tremor Severity Scores Increase at a Uniform Rate? Jun 1, 2022
- Ability of Swept-source OCT and OCT-angiography to detect neuroretinal and vasculature changes in patients with Parkinson disease and essential tremor May 31, 2022
- Effects of Deep Brain Stimulation on Lower Urinary Tract Function in Neurological Patients May 31, 2022
- Altered thalamic connectivity due to focused ultrasound thalamotomy in patients with essential tremor May 30, 2022
- Benefits and Risks of a Staged-Bilateral VIM Versus Unilateral VIM DBS for Essential Tremor May 26, 2022
- Reply to “Deep Brain Stimulation for Tremor: Direct Targeting of a Novel Imaging Biomarker” May 24, 2022
- The Italian tremor Network (TITAN): rationale, design and preliminary findings May 23, 2022
- Transcranial high-intensity Magnetic Resonance-guided focused ultrasound (tcMRgFUS) – safety and impacts on tremor severity and quality of life May 23, 2022
- Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy May 22, 2022
Clinical Trials
- RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor Sep 14, 2022
- Algorithms for Programming DBS Systems for ET Aug 4, 2022
- Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands Jul 29, 2022
- Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor Jul 26, 2022
- Evaluate SAGE-547 in Participants With Essential Tremor Jun 29, 2022
- tSMS in Essential Tremor Jun 6, 2022
- The Swedish Essential Tremor (SWEET) Trial May 25, 2022
- A Clinical Trial of PRAX-114 in Participants With Essential Tremor May 24, 2022
- A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor May 9, 2022
- Neurophysiologic Assessment of ET Patients Treated by Vim DBS May 5, 2022
- Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia Apr 7, 2022
- Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation Apr 4, 2022
- Efficacy, Safety, and Pharmacokinetics of ES-481 in Adult Patients With Essential Tremors Feb 10, 2022
- Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor Jan 31, 2022
- Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation Jan 28, 2022
- Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma Jan 28, 2022
- Interphase Gap in Biphasic Stimulation in DBS for ET Jan 5, 2022
- Study to Evaluate SAGE-324 in Participants With Essential Tremors Dec 29, 2021
- Repetitive Transcranial Magnetic Stimulation in Essential Tremors Patients Dec 15, 2021
- A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET) Nov 17, 2021
- The Effects of Vibrotactile Stimulation in Patients With Movement Disorders Nov 4, 2021
- Neurofeedback Using Implanted Deep Brain Stimulation Electrodes Nov 1, 2021
- DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET) Oct 27, 2021
- Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001) Oct 22, 2021
- A Phase 2 RCT Study of CX-8998 for Essential Tremor Oct 22, 2021
- New Stereotactic Frame System for Neurosurgery Oct 14, 2021
- ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 16, 2021
- Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 8, 2021
- Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor Sep 8, 2021
- ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders Sep 8, 2021
- [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson’s Diseases and Essential Tremor Sep 5, 2021
- A Study to Evaluate the Effectiveness and Safety of ExAblate MRgFUS on Essential Tremor Sep 5, 2021
- Cyclic Deep Brain Stimulation in Essential Tremor Sep 2, 2021
- Cerebello-thalamo-cortical Coupling in Essential Tremor Aug 30, 2021
- A Clinical Trial of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- A Clinical Trial of 3 Doses of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives Aug 13, 2021
- Responsive Deep Brain Stimulator for Essential Tremor Aug 12, 2021
- Cortical-Basal Ganglia Speech Networks Aug 9, 2021
- Deep braIn Stimulation for Tremor TractographIC Versus Traditional Jul 28, 2021
- Sensory-specific Peripheral Stimulation for Tremor Management Jul 21, 2021
- Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity Jul 16, 2021
- Effects of Stimulation Patterns of Deep Brain Stimulation Jul 2, 2021
- Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson’s Disease and Tremor May 18, 2021
- Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor May 11, 2021
- UPDATED: Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Directional Versus Nondirectional DBS for ET Apr 2, 2021
- Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
- Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
- Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
- RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
- Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
- A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
- Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
- Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
- A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
- Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
- A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
- Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
- Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
- Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
- A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021
- Wearable Sensor for Responsive DBS for ET Jan 14, 2021
- Optimization of VIM Targeting in Essential Tremor Surgery Jan 12, 2021
- A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Dec 23, 2020
- Trial of Cannabis for Essential Tremor Dec 21, 2020
- Mapping the Target for the MRgFUS Treatment of Tremor Dec 10, 2020
- Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings Dec 8, 2020
- Deep Brain Stimulation Therapy in Movement Disorders Nov 17, 2020
- Physiology, Imaging and Modeling of Essential Tremor Nov 12, 2020
- Demand-driven Management of Essential Tremor Nov 5, 2020
- Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? Oct 30, 2020
- Masotherapy With Neural Tension in Patients With Parkinson’s Disease Oct 23, 2020
- A Clinical Study to Evaluate CAD-1883 in Essential Tremor Oct 14, 2020
- Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
- Alternating Current Stimulation for Essential Tremor Sep 2, 2020
- Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
- Trial of Cannabis for Essential Tremor May 29, 2020
