This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects
Last updated: 9 months ago
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News
- Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
- First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
- Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
- Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
- INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
- New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
- New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
- Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
- Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
- New radiation therapy shows promise for treating essential tremor Jun 14, 2019
Research
- Corrigendum to: Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation Jun 11, 2021
- Behavioral Therapy for Tremor or Dystonia Affecting Voice in Speakers with Hyperkinetic Dysarthria: A Systematic Review Jun 7, 2021
- Radiofrequency Ablation for Movement Disorders: Risk Factors for Intracerebral Hemorrhage, a Retrospective Analysis Jun 7, 2021
- Tremor and Parkinsonism in Chromosomopathies – A Systematic Review May 31, 2021
- Spinocerebellar ataxia type 21 (TMEM240) with tremor and dystonia May 30, 2021
- Can Plasma alpha-Synuclein Help Us to Differentiate Parkinson’s Disease from Essential Tremor? May 28, 2021
- Genomic Markers for Essential Tremor May 27, 2021
- The Magnetic Resonance Imaging (MRI)-Directed Implantable Guide Tube Technique: Accuracy and Applications in Deep Brain Stimulation May 24, 2021
- Technical and operative factors affecting magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: experience from 250 treatments May 20, 2021
- Thalamic but Not Subthalamic Neuromodulation Simplifies Word Use in Spontaneous Language May 19, 2021
- Physical Activity as a Predictor of Cognitive Decline in an Elderly Essential Tremor Cohort: A Prospective, Longitudinal Study May 19, 2021
- Neuroimaging Assessment of Nigrosome 1 with a Multiecho Gre Magnetic Resonance Sequence in the Differentiation Between Parkinsons Disease from Essential Tremor and Healthy Individuals May 18, 2021
- The Distribution of Skull Score and Skull Density Ratio in Tremor Patients for MR-Guided Focused Ultrasound Thalamotomy May 16, 2021
- Fragile X-associated tremor/ataxia syndrome: pathophysiology and management May 14, 2021
- Clinical-Instrumental patterns of neurodegeneration in Essential Tremor: A data-driven approach May 14, 2021
- Delayed intracerebral hemorrhage associated with placement of a deep brain stimulating electrode over two years prior May 12, 2021
- Magnetic resonance-guided focused ultrasound treatment for essential tremor shows sustained efficacy: a meta-analysis May 12, 2021
- Tapping the Potential of Multimodal Non-invasive Brain Stimulation to Elucidate the Pathophysiology of Movement Disorders May 11, 2021
- Therapeutic Development for CGG Repeat Expansion-Associated Neurodegeneration May 11, 2021
- Baseline Infection Burden and Cognitive Function in Elders with Essential Tremor May 11, 2021
- Risk of Infection after Deep Brain Stimulation Surgery with Externalization and Local-Field Potential Recordings: Twelve-Year Experience from a Single Institution May 10, 2021
- Progressive cerebellar atrophy in a patient with complex II and III deficiency and a novel deleterious variant in SDHA: A Counseling Conundrum May 8, 2021
- Outcome and Complications of MR Guided Focused Ultrasound for Essential Tremor: A Systematic Review and Meta-Analysis May 6, 2021
- GABA, Glutamate, and NAA Levels in the Deep Cerebellar Nuclei of Essential Tremor Patients May 5, 2021
- Device profile of ExAblate Neuro 4000, the leading system for brain Magnetic Resonance Guided Focused Ultrasound technology; an overview of its safety and efficacy in the treatment of medically refractory essential tremor May 5, 2021
- A deep explainable artificial intelligent framework for neurological disorders discrimination May 5, 2021
- Whole-genome study of a multigenerational family with essential tremor May 4, 2021
- Bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of essential tremor: a case series study Apr 27, 2021
- Tremor assessment using smartphone sensor data and fuzzy reasoning Apr 25, 2021
- Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation Apr 22, 2021
- Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes Apr 22, 2021
- High-fidelity transmission of high-frequency burst stimuli from peripheral nerve to thalamic nuclei in children with dystonia Apr 19, 2021
- Clinical Features of Essential Voice Tremor and Associations with Tremor Severity and Response to Octanoic Acid Treatment Apr 17, 2021
- Fragmentary Hypnic Myoclonus and Other Isolated Motor Phenomena of Sleep Apr 16, 2021
- What might cervical vestibular-evoked myogenic potential abnormalities mean in essential tremor? Apr 15, 2021
- Hemi-parkinsonism and return of essential tremors after MRgFUS thalamotomy: Case report and review of procedural complications affecting ventral thalamic nuclei Apr 15, 2021
- Machine Learning Will Extend the Clinical Utility of Adaptive Deep Brain Stimulation Apr 14, 2021
- Ventralis oralis anterior (Voa) deep brain stimulation plus Gamma Knife thalamotomy in an elderly patient with essential tremor: A case report Apr 13, 2021
- The global prevalence of essential tremor, with emphasis on age and sex: A meta-analysis Apr 10, 2021
- Developing a Consistent, Reproducible Botulinum Toxin Type A Dosing Method for Upper Limb Tremor by Kinematic Analysis Apr 8, 2021
- Agmatine has beneficial effect on harmaline-induced essential tremor in rat Apr 7, 2021
- Optimizing deep brain stimulation based on isostable amplitude in essential tremor patient models Apr 6, 2021
- Lateralized Effect of Thalamic Deep Brain Stimulation Location on Verbal Abstraction Apr 5, 2021
- The Signature of Primary Writing Tremor Is Dystonic Mar 30, 2021
- Fatigue in hypokinetic, hyperkinetic, and functional movement disorders Mar 29, 2021
- The Brain Connectome after Gamma Knife Radiosurgery of the Ventro-Intermediate Nucleus for Tremor: Marseille-Lausanne Radiobiology Study Protocol Mar 29, 2021
- Disrupted brain gray matter networks in drug-naive participants with essential tremor Mar 29, 2021
- Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson’s Disease in a Movement Disorders Clinic Mar 29, 2021
- Assessment of Motor Dysfunction with Virtual Reality in Patients Undergoing [123 I]FP-CIT SPECT/CT Brain Imaging Mar 26, 2021
- Abnormalities of intrinsic brain activity in essential tremor: A meta-analysis of resting-state functional imaging Mar 26, 2021
- The Essential Tremors: Evolving Concepts of a Family of Diseases Mar 25, 2021
- Essential Tremor versus “ET-plus”: A Detailed Postmortem Study of Cerebellar Pathology Mar 25, 2021
- A Phase 2 Proof-of-Concept, Randomized, Placebo-Controlled Trial of CX-8998 in Essential Tremor Mar 25, 2021
- The Progression of Essential Tremors: Illustrative Videos Mar 24, 2021
- ‘Essential Tremor’ Phenotype in FMR1 Premutation/Gray Zone Sibling Series: Exploring Possible Genetic Modifiers Mar 23, 2021
- Anatomical texture patterns identify cerebellar distinctions between essential tremor and Parkinson’s disease Mar 23, 2021
- Sleep Disorders in Patients with Essential Tremor Mar 22, 2021
- Spinal astroglial cannabinoid receptors control pathological tremor Mar 18, 2021
- Directional Stimulation in Parkinson’s Disease and Essential Tremor: The Cleveland Clinic Experience Mar 17, 2021
- Expanding the Spectrum of Movement Disorders Associated With C9orf72 Hexanucleotide Expansions Mar 15, 2021
- No evidence of iron deposition in essential tremor: a susceptibility-weighted imaging study Mar 15, 2021
- A Voxel-Wise Meta-Analysis on the Cerebellum in Essential Tremor Mar 14, 2021
- Increased structural connectivity of thalamic stimulation sites to motor cortex relates to tremor suppression Mar 13, 2021
- The Decline of Deep Brain Stimulation for Obsessive-Compulsive Disorder Following FDA Humanitarian Device Exemption Approval Mar 11, 2021
- Disrupted Brain Network Topology in Drug-naive Essential Tremor Patients with and Without Depression : A Resting State Functional Magnetic Resonance Imaging Study Mar 9, 2021
- Classification of vocal tremor using updated consensus-based tremor classification criteria Mar 9, 2021
- Speech Function Following Deep Brain Stimulation of the Caudal Zona Incerta: Effects of Habitual and High-Amplitude Stimulation Mar 1, 2021
- Abnormal movements in hospitalized COVID-19 patients: A case series Feb 26, 2021
- Descriptive epidemiological study on patients with movement disorders, with emphasis on Parkinson’s disease Feb 24, 2021
- Clinical and Imaging Profile of Patients with Palatal Tremor Feb 18, 2021
- Peripheral electrical stimulation to reduce pathological tremor: a review Feb 17, 2021
- Cognitive subtypes in individuals with essential tremor seeking deep brain stimulation Feb 14, 2021
- Altered local and matrix functional connectivity in depressed essential tremor patients Feb 11, 2021
- Automatic Classification of Healthy Subjects and Patients With Essential Vocal Tremor Using Probabilistic Source-Filter Model Based Noise Robust Pitch Estimation Feb 10, 2021
- Quality of life in isolated dystonia: non-motor manifestations matter Feb 9, 2021
- Adoption of focused ultrasound thalamotomy for essential tremor: why so much fuss about FUS? Feb 9, 2021
- Clock-Drawing Tasks as Predictive Measurements for Disease Classification Among Patients With Parkinson’s Disease and Essential Tremor Feb 9, 2021
- Closed-Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials Feb 8, 2021
- Smell tests to distinguish Parkinson’s disease from other neurological disorders: a systematic review and meta-analysis Feb 6, 2021
- Voice Analysis with Machine Learning: One Step Closer to an Objective Diagnosis of Essential Tremor Feb 4, 2021
- Prescribing cascades and medications most frequently involved in pain therapy: a review Feb 1, 2021
- Bilateral Subdural Hygromas After Deep Brain Stimulation Implantation in the Setting of Unrecognized Intracranial Hypotension Jan 30, 2021
- A case of Anti-LGi-1 antibody positive autoimmune epilepsy following deep brain stimulator implantation for essential tremor Jan 30, 2021
- Development and Validation of a New Wearable Mobile Device for the Automated Detection of Resting Tremor in Parkinson’s Disease and Essential Tremor Jan 29, 2021
- The spiral axis: A comparison of unaffected first-degree relatives of essential tremor cases vs. controls Jan 28, 2021
- Non-motor symptoms in essential tremor, akinetic rigid and tremor-dominant subtypes of Parkinson’s disease Jan 27, 2021
- Increased Climbing Fiber Lateral Crossings on Purkinje Cell Dendrites in the Cerebellar Hemisphere in Essential Tremor Jan 26, 2021
- Orthostatic Hypotension in Elderly Patients with Essential Tremor Jan 21, 2021
- Commentary: Focused Ultrasound Thalamotomy for Refractory Essential Tremor: A Japanese Multicenter Single-Arm Study Jan 20, 2021
- Focused Ultrasound Thalamotomy for Refractory Essential Tremor: A Japanese Multicenter Single-Arm Study Jan 19, 2021
- Deep Brain Stimulation in Alzheimer’s Disease: Targeting the Nucleus Basalis of Meynert Jan 19, 2021
- Combination targeting of subthalamic nucleus and ventral intermediate thalamic nucleus with a single trajectory in deep brain stimulation for tremor-dominant Parkinson’s disease Jan 18, 2021
- Exploring Interrater Disagreement on Essential Tremor Using a Standardized Tremor Elements Assessment Jan 18, 2021
- A novel approach to differential diagnosis of Parkinson’s disease and essential tremor Jan 18, 2021
- DBS targeting for essential tremor using intersectional dentato-rubro-thalamic tractography and direct proton density visualization of the VIM: technical note on 2 cases Jan 14, 2021
- Botulinum Toxin Monotherapy for the Treatment of Essential Tremor: Life Quality Effect Jan 14, 2021
- A single oral dose of cannabidiol did not reduce upper limb tremor in patients with essential tremor Jan 13, 2021
- Objective Detection of Microtremors in Netrin-G2 Knockout Mice Jan 13, 2021
- Descriptive epidemiological study on patients with movement disorders, with emphasis on Parkinson’s disease Jan 13, 2021
- Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence Jan 13, 2021
Clinical Trials
- Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson’s Disease and Tremor May 18, 2021
- Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor May 11, 2021
- UPDATED: Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Directional Versus Nondirectional DBS for ET Apr 2, 2021
- Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
- Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
- Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
- RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
- Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
- A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
- Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
- Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
- A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
- Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
- A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
- Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
- Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
- Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
- A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021
- Wearable Sensor for Responsive DBS for ET Jan 14, 2021
- Optimization of VIM Targeting in Essential Tremor Surgery Jan 12, 2021
- A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Dec 23, 2020
- Trial of Cannabis for Essential Tremor Dec 21, 2020
- Mapping the Target for the MRgFUS Treatment of Tremor Dec 10, 2020
- Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings Dec 8, 2020
- Deep Brain Stimulation Therapy in Movement Disorders Nov 17, 2020
- Physiology, Imaging and Modeling of Essential Tremor Nov 12, 2020
- Demand-driven Management of Essential Tremor Nov 5, 2020
- Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? Oct 30, 2020
- Masotherapy With Neural Tension in Patients With Parkinson’s Disease Oct 23, 2020
- A Clinical Study to Evaluate CAD-1883 in Essential Tremor Oct 14, 2020
- Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
- Alternating Current Stimulation for Essential Tremor Sep 2, 2020
- Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
- Trial of Cannabis for Essential Tremor May 29, 2020
