This page tracks new and upcoming treatment options for essential tremor (ET). What’s in development? What’s promising? What’s available soon? Current topics include JZP-385, CX-8998, SAGE-324, deep brain stimulation, MRgFUS, cannabis, CAD-1883, and more. Jump to section: News, Research, Clinical Trials, Projects
Last updated: 2 years ago
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News
- Rush Focused Ultrasound Program Changing Lives of Patients With Movement Disorders Sep 29, 2020
- First Real-World Evidence Demonstrates Cala Trio’s Effectiveness in Essential Tremor with Individually Calibrated, Non-Invasive Stimulation Sep 14, 2020
- Boston Scientific Launches Vercise Genus™ Deep Brain Stimulation (DBS) System In Europe Sep 9, 2020
- Dr. Kuo Honored for Essential Tremor Research Sep 2, 2020
- INSIGHTEC’s MR-Guided Focused Ultrasound Treatment for Essential Tremor Receives Complete Medicare Coverage in the US Jul 13, 2020
- New Focused Ultrasound Treatment to Eliminate Essential Tremor Mar 11, 2020
- New Study Finds Overactive Brain Waves Cause a Common Movement Disorder Called Essential Tremor Jan 15, 2020
- Overactive Brain Waves Trigger Essential Tremor Jan 15, 2020
- Ultrasound treatment for essential tremor may be effective up to three years later Nov 20, 2019
- New radiation therapy shows promise for treating essential tremor Jun 14, 2019
Research
- T-type calcium channels as therapeutic targets in essential tremor and Parkinson’s disease Feb 4, 2023
- Additional Role of Midbrain F-18 FP-CIT Uptake on PET in Evaluation of Essential Tremor and Parkinsonism Feb 3, 2023
- Wearable sensor-based gait analysis to discriminate early Parkinson’s disease from essential tremor Feb 1, 2023
- Bilateral Radiofrequency Ventral Intermediate Thalamotomy for Essential Tremor Jan 31, 2023
- Connectomic Basis for Tremor Control in Stereotactic Radiosurgical Thalamotomy Jan 26, 2023
- Gait Function after High-Intensity Focused Ultrasound Thalamotomy for Essential Tremor: Searching for Technique Optimization Jan 25, 2023
- Focused Ultrasound Thalamotomy: Correlation of Postoperative Imaging with Neuropathological Findings Jan 25, 2023
- Cerebellar α6GABAA Receptors as a Therapeutic Target for Essential Tremor: Proof-of-Concept Study with Ethanol and Pyrazoloquinolinones Jan 25, 2023
- Perampanel: Medical Alternative for Essential Tremor? Jan 25, 2023
- Essential Tremor accentuates the pattern of tremor-band coherence between upper-limb muscles Jan 25, 2023
- Chronic inflammatory demyelinating polyradiculoneuropathy associated tremor: Phenotype and pathogenesis Jan 24, 2023
- Han family with essential tremor caused by the P421L variant of the TENM4 gene in China Jan 22, 2023
- Commentary: Time trends in the incidence of essential tremor: Evidences from UK and France primary care data Jan 19, 2023
- An Institutional Experience of Directional Deep Brain Stimulation and a Review of the Literature Jan 17, 2023
- Limb positioning and magnitude of postural tremor ratings: A study of 100 essential tremor cases Jan 12, 2023
- Expression of Concern: Hcn1 Is a Tremorgenic Genetic Component in a Rat Model of Essential Tremor Jan 11, 2023
- Reproducibility of cerebellar involvement as quantified by consensus structural MRI biomarkers in advanced essential tremor Jan 11, 2023
- Brain microstructural changes in essential tremor patients and correlations with clinical characteristics: a diffusion kurtosis imaging study Jan 6, 2023
- Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains Jan 5, 2023
- Classification of Kinematic and Electromyographic Signals Associated with Pathological Tremor Using Machine and Deep Learning Jan 5, 2023
- Differential contributions of depression, apathy, and anxiety to neuropsychological performance in Parkinson’s disease versus essential tremor Jan 4, 2023
- Upper Limb Function but Not Proprioception is Impaired in Essential Tremor: A Between-Groups Study and Causal Mediation Analysis Jan 3, 2023
- Infantile Tremor Syndrome With Movement Disorder: Current Perspective Dec 29, 2022
- Diagnosis and Treatment of Tremor in Parkinson’s Disease Using Mechanical Devices Dec 28, 2022
- Tremor Dec 27, 2022
- The effect of tremor on disability assessment in chronic inflammatory demyelinating polyradiculoneuropathy Dec 26, 2022
- Noninvasive neuroimaging provides evidence for deterioration of the glymphatic system in Parkinson’s disease relative to essential tremor Dec 24, 2022
- Skin-related complications following deep brain stimulation surgery: A single-center retrospective analysis of 525 patients who underwent DBS surgery Dec 23, 2022
- Analyses of correct responses and errors on measures of verbal fluency among Parkinson’s disease and essential tremor patients Dec 22, 2022
- Cosmetic considerations for placement of deep brain stimulation pulse generator: the submammary subfascial approach Dec 14, 2022
- Imaging Modalities Used for Frameless and Fiducial-Less Deep Brain Stimulation: A Single Centre Exploratory Study among Parkinson’s Disease Cases Dec 13, 2022
- Visualizing the deep cerebellar nuclei using quantitative susceptibility mapping: An application in healthy controls, Parkinson’s disease patients and essential tremor patients Dec 11, 2022
- Exploring the heterogeneous morphometric data in essential tremor with probabilistic modelling Dec 6, 2022
- Magnetic resonance-guided focused ultrasound for the treatment of tremor Dec 5, 2022
- Thalamic Segmentation and Neural Activation Modeling Based on Individual Tissue Microstructure in Deep Brain Stimulation for Essential Tremor Dec 2, 2022
- Assessing the impact of MR-guided focused ultrasound thalamotomy on brain activity and connectivity in patients with essential tremor Dec 1, 2022
- Cognitive outcomes after focused ultrasound thalamotomy for tremor: Results from the COGNIFUS (COGNitive in Focused UltraSound) study Nov 28, 2022
- Identifying and distinguishing of essential tremor and Parkinson’s disease with grouped stability analysis based on searchlight-based MVPA Nov 28, 2022
- Longitudinal study of clinical and neurophysiological features in essential tremor Nov 27, 2022
- Deep brain stimulation of the dentato-rubro-thalamic tract in a case of Holmes tremor: a constrained spherical deconvolution (CSD)-guided procedure Nov 26, 2022
- Cognitive effects of unilateral thalamotomy for tremor: a meta-analysis Nov 23, 2022
- Interphase Gaps in Symmetric Biphasic Pulses Reduce the Therapeutic Window in Ventral Intermediate Nucleus of the Thalamus-Deep Brain Stimulation for Essential Tremor Nov 17, 2022
- Voice Tremor and Botulinum Neurotoxin Therapy: A Contemporary Review Nov 8, 2022
- Oculomotor impairments in de novo Parkinson’s disease Nov 8, 2022
- Necessity of MRI-compatible deep brain stimulation systems – Hits and hints for decision making Nov 8, 2022
- Combined Short-Pulse and Directional Deep Brain Stimulation of the Thalamic Ventral Intermediate Area for Essential Tremor Nov 8, 2022
- Quality and Reliability Analysis of Essential Tremor Disease Information on Social Media: The Study of YouTube Nov 8, 2022
- Closed loop deep brain stimulation: A systematic scoping review Nov 6, 2022
- Identification of essential tremor based on resting-state functional connectivity Nov 3, 2022
- Combined brain network topological metrics with machine learning algorithms to identify essential tremor Nov 2, 2022
- Reliability of Self-report Data on Age of Onset in Essential Tremor: Data from a Prospective, Longitudinal Cohort Nov 1, 2022
- Increased Medical Comorbidities in Essential Tremor-A Wake-up Call? Nov 1, 2022
- Satisfaction With Telemedicine Consultation as Follow-Up Visit in Patients with Parkinsonism and Essential Tremor in during the Covid-19 Pandemic Oct 31, 2022
- Exploring Patient’s Preference of Patient-Reported Outcome Measures in Laryngeal Movement Disorders Oct 31, 2022
- Cerebello-Thalamo-Cortical MR Spectroscopy in Patients with Essential Tremor Undergoing MRgFUS Thalamotomy: A Pilot Study Oct 30, 2022
- Lipid profile in Parkinson’s disease: The potential role of brain-derived neurotrophic factor Oct 29, 2022
- Commentary on: A Network Approach to Understanding the Effects of Focused Ultrasound for Essential Tremor: Insights into Pathophysiology, Treatment, and Imaging Biomarkers Oct 27, 2022
- Multimodal imaging of essential tremor and dystonic tremor Oct 25, 2022
- Zonisamide add-on in tremor-dominant Parkinson’s disease- A randomized controlled clinical trial Oct 25, 2022
- The problem of pharmacoresistant tremor in Parkinson’s disease and essential tremor Oct 24, 2022
- Hybrid surgery of ventral intermediate nucleus thalamotomy using magnetic resonance-guided focus ultrasound and modulation by deep brain stimulation controls bilateral essential tremor Oct 21, 2022
- First experience of thalamotomy by focused ultrasound under MR-guided navigation in the treatment of tremor. Neuroimaging follow-up. Case report and literature review Oct 17, 2022
- The effect of regional white matter hyperintensities on essential tremor subtypes and severity Oct 16, 2022
- Isolated slow orthostatic tremor of the trunk Oct 16, 2022
- Gene Expression Analysis of Laser-Captured Purkinje Cells in the Essential Tremor Cerebellum Oct 14, 2022
- The Hidden Burden of Disease and Treatment Experiences of Patients with Essential Tremor: A Retrospective Claims Data Analysis Oct 14, 2022
- Cluster analysis of clinical, biochemical and electrophysiological features of essential tremor patients. Exploratory study Oct 13, 2022
- Deep brain stimulation for neurological disorders: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials Oct 13, 2022
- Diagnosis and Treatment of Essential Tremor Oct 12, 2022
- MRI-guided focused-ultrasound thalamotomy in essential tremor: Immediate and delayed changes in cortico-muscular coherence and cortico-cortical out-strength Oct 12, 2022
- DDOST-CDG: Clinical and Molecular Characterization of a Third Patient with a Milder and a Predominantly Movement Disorder Phenotype Oct 10, 2022
- Differences in Olivo-Cerebellar Circuit and Cerebellar Network Connectivity in Essential Tremor: a Resting State fMRI Study Oct 10, 2022
- Accidental Falls in Patients with Hyperkinetic Movement Disorders: A Systematic Review Oct 7, 2022
- Deep brain stimulation and spinal cord stimulation for orthostatic tremor: A systematic review Oct 6, 2022
- Development of ETStig, a measure for stigma in essential tremor Oct 4, 2022
- Locus coeruleus degeneration and cerebellar gray matter changes in essential tremor Oct 4, 2022
- Annual health care costs among Medicare Beneficiaries with essential tremor Oct 2, 2022
- Morphometric features of drug-resistant essential tremor and recovery after stereotactic radiosurgical thalamotomy Sep 29, 2022
- Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology Sep 29, 2022
- Prediction of Pathological Tremor Signals Using Long Short-Term Memory Neural Networks Sep 28, 2022
- Functional connectivity of the cortico-subcortical sensorimotor loop is modulated by the severity of nigrostriatal dopaminergic denervation in Parkinson’s Disease Sep 28, 2022
- Non-Persistence of Tremorolytic Effect of Perampanel in Essential Tremor: Real-World Experience with 50 Patients Sep 25, 2022
- Noradrenergic Pathway to the Cerebellum: the Study Must Go On Sep 22, 2022
- The Cost-Effectiveness of unilateral magnetic Resonance-Guided focused ultrasound in comparison to unilateral deep brain stimulation for the treatment of medically refractory essential tremor in England Sep 20, 2022
- Time trends in the incidence of essential tremor: Evidences from UK and France primary care data Sep 20, 2022
- Challenging functional connectivity data: machine learning application on essential tremor recognition Sep 19, 2022
- Optimizing Botox regimens in patients with adductor spasmodic dysphonia and essential tremor of voice: A 31-year experience Sep 19, 2022
- Epicranial Direct Current Stimulation Suppresses Harmaline Tremor in Rats Sep 15, 2022
- Association of Diet With Essential Tremor: A Narrative Review Sep 14, 2022
- Clinical Features and Reclassification of Essential Tremor with NOTCH2NLC GGC Repeat Expansions based on a long-term follow-up Sep 10, 2022
- Clinicopathologic Correlations of Jaw Tremor in a Longitudinal Aging Study Sep 9, 2022
- Visuomotor Adaptation Deficits in Patients with Essential Tremor Sep 9, 2022
- Treatment-Specific Network Modulation of MRI-Guided Focused Ultrasound Thalamotomy in Essential Tremor : Modulation of ET-Related Network by MRgFUS Thalamotomy Sep 9, 2022
- Does Head Tremor Predict Postural Instability After Bilateral Thalamic Stimulation in Essential Tremor? Sep 9, 2022
- A Wearable In-home Tremor Assessment System via Virtual Reality Environment for the Activities in Daily Lives (ADLs) Sep 8, 2022
- Analysis of GIPC1 CGG repeat expansions in essential tremor Sep 7, 2022
- Physiological Recordings of the Cerebellum in Movement Disorders Sep 6, 2022
- Real-World Evidence of Transcutaneous Afferent Patterned Stimulation for Essential Tremor Sep 1, 2022
- Evaluation of Cerebellar Ataxic Patients Aug 31, 2022
- Case report – Asterixis Post High Frequency Focused-Ultrasound Thalamotomy Aug 30, 2022
Clinical Trials
- Electroclinical Correlates in Essential Tremor Jan 5, 2023
- Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor Dec 12, 2022
- Gamma Knife Radiosurgery for Treatment of Essential Tremor Nov 22, 2022
- MRgFUS Thalamotomy for Therapy-Resistant Tremor-related Disease With Low SDR Value Nov 22, 2022
- RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor Sep 14, 2022
- Algorithms for Programming DBS Systems for ET Aug 4, 2022
- Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands Jul 29, 2022
- Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor Jul 26, 2022
- Evaluate SAGE-547 in Participants With Essential Tremor Jun 29, 2022
- tSMS in Essential Tremor Jun 6, 2022
- The Swedish Essential Tremor (SWEET) Trial May 25, 2022
- A Clinical Trial of PRAX-114 in Participants With Essential Tremor May 24, 2022
- A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor May 9, 2022
- Neurophysiologic Assessment of ET Patients Treated by Vim DBS May 5, 2022
- Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia Apr 7, 2022
- Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation Apr 4, 2022
- Efficacy, Safety, and Pharmacokinetics of ES-481 in Adult Patients With Essential Tremors Feb 10, 2022
- Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor Jan 31, 2022
- Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation Jan 28, 2022
- Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma Jan 28, 2022
- Interphase Gap in Biphasic Stimulation in DBS for ET Jan 5, 2022
- Study to Evaluate SAGE-324 in Participants With Essential Tremors Dec 29, 2021
- Repetitive Transcranial Magnetic Stimulation in Essential Tremors Patients Dec 15, 2021
- A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET) Nov 17, 2021
- The Effects of Vibrotactile Stimulation in Patients With Movement Disorders Nov 4, 2021
- Neurofeedback Using Implanted Deep Brain Stimulation Electrodes Nov 1, 2021
- DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET) Oct 27, 2021
- Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001) Oct 22, 2021
- A Phase 2 RCT Study of CX-8998 for Essential Tremor Oct 22, 2021
- New Stereotactic Frame System for Neurosurgery Oct 14, 2021
- ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 16, 2021
- Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors Sep 8, 2021
- Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor Sep 8, 2021
- ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders Sep 8, 2021
- [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson’s Diseases and Essential Tremor Sep 5, 2021
- A Study to Evaluate the Effectiveness and Safety of ExAblate MRgFUS on Essential Tremor Sep 5, 2021
- Cyclic Deep Brain Stimulation in Essential Tremor Sep 2, 2021
- Cerebello-thalamo-cortical Coupling in Essential Tremor Aug 30, 2021
- A Clinical Trial of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- A Clinical Trial of 3 Doses of PRAX-944 in Participants With Essential Tremor Aug 26, 2021
- Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives Aug 13, 2021
- Responsive Deep Brain Stimulator for Essential Tremor Aug 12, 2021
- Cortical-Basal Ganglia Speech Networks Aug 9, 2021
- Deep braIn Stimulation for Tremor TractographIC Versus Traditional Jul 28, 2021
- Sensory-specific Peripheral Stimulation for Tremor Management Jul 21, 2021
- Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity Jul 16, 2021
- Effects of Stimulation Patterns of Deep Brain Stimulation Jul 2, 2021
- Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson’s Disease and Tremor May 18, 2021
- Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor May 11, 2021
- UPDATED: Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Bilateral Essential Tremor Treatment With FUS Apr 23, 2021
- Directional Versus Nondirectional DBS for ET Apr 2, 2021
- Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor Mar 18, 2021
- Pregabalin in the Treatment of Essential Tremor Mar 12, 2021
- Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor Mar 11, 2021
- RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson’s Disease Mar 3, 2021
- Deep Brain Stimulation (DBS) for the Suppression of Tremor Feb 26, 2021
- A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm Feb 23, 2021
- Botulinum Toxin A to Treat Arm Tremor Feb 18, 2021
- Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study Feb 18, 2021
- A Study to Evaluate SAGE-217 in Participants With Essential Tremor Feb 17, 2021
- Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract Feb 17, 2021
- Bilateral Essential Tremor Treatment With Gamma Knife Feb 10, 2021
- A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients Feb 8, 2021
- Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor Jan 28, 2021
- Bilateral Treatment of Medication Refractory Essential Tremor Jan 27, 2021
- Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL) Jan 27, 2021
- Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders Jan 26, 2021
- A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor Jan 22, 2021
- Wearable Sensor for Responsive DBS for ET Jan 14, 2021
- Optimization of VIM Targeting in Essential Tremor Surgery Jan 12, 2021
- A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor Dec 23, 2020
- Trial of Cannabis for Essential Tremor Dec 21, 2020
- Mapping the Target for the MRgFUS Treatment of Tremor Dec 10, 2020
- Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings Dec 8, 2020
- Deep Brain Stimulation Therapy in Movement Disorders Nov 17, 2020
- Physiology, Imaging and Modeling of Essential Tremor Nov 12, 2020
- Demand-driven Management of Essential Tremor Nov 5, 2020
- Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? Oct 30, 2020
- Masotherapy With Neural Tension in Patients With Parkinson’s Disease Oct 23, 2020
- A Clinical Study to Evaluate CAD-1883 in Essential Tremor Oct 14, 2020
- Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool Sep 30, 2020
- Alternating Current Stimulation for Essential Tremor Sep 2, 2020
- Bilateral Essential Tremor Treatment With Magnetic Resonance-guided Focused Ultrasound (FUS) Aug 6, 2020
- Trial of Cannabis for Essential Tremor May 29, 2020
